Evidence map›Paper›PMID 38464636›Full record

ArticleJournal of education and health promotion2023

Study to determine the epidemiology of treatment-resistant depression among the Saudi Arabian population: A cross-sectional study.

Abdullah S Alshehri, Abdullah M Algarni, Hussein Ahmed M Almahdi, Abdulkhaliq Hadi H Asiri, Hassan Yahya M Asiri, Ahmad Abdullah H Alsulami, Hassan Ahmed A Alasiri, Nawaf Khalid A Hassan

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Article in Journal of education and health promotion, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdullah S AlshehriDepartment of Psychiatry, King Khalid University Medical City, Abha, Saudi Arabia.
Abdullah M AlgarniFamily Medicine Consultant, Aseer Central Hospital, Abha, Aseer Region, Saudi Arabia.
Hussein Ahmed M AlmahdiMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Abdulkhaliq Hadi H AsiriMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Hassan Yahya M AsiriMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Ahmad Abdullah H AlsulamiMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Hassan Ahmed A AlasiriMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Nawaf Khalid A HassanMBBS Undergraduate, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is a common mental health disorder that affects millions of people worldwide. Globally, major depressive disorder (MDD) is a public health concern; nearly, it affects more than 300 million people. The coronavirus disease 2019 (COVID-19) pandemic lockdown, travel restrictions, social distancing, and COVID-19 vaccine acceptance have aggravated psychological disorders, such as depression and suicidal tendencies. Treatment-resistant depression (TRD) is typically defined as a lack of response to at least two different antidepressant medications or psychotherapies. TRD is common and has been associated with higher comorbidities and prolonged duration of illness, leading to a substantial medical and economic burden. MATERIALS AND

methodsA cross-sectional study was designed to determine the epidemiology and estimate the prevalence of TRD in Abha City, Assir Region, Kingdom of Saudi Arabia. The study includes adult patients who were attended to the psychiatry department and aged 18-65 years diagnosed with major depressive depression. A total of 651 study participants were recruited.

resultsOf the total 651 depressive disorder cases, 134 (20.6%) were reported as TRD and the remaining 517 (79.4%) were nontreatment-resistant depressive cases. Of the 651 depression participants, 176 (27%) were males and 475 (73%) were females. More than one-quarter (180 (28%)) had been associated with chronic morbidity. One-tenth of the depressive patients were suffering from thyroid disorders, followed by hypertension (10%), autoimmune diseases (10%), and diabetes mellitus (8%).

conclusionsTRD emerged as a threat to public health and challenging psychiatric care providers, and further innovative techniques and effective newer drugs to treat depression need to be researched. The treatment complaint mechanism is warranted, encouraging people to get treatment from the psychiatrist by removing the stigma of mental illness, which is needed to improve the quality of life of TRD patients.

Indexed as

AntidepressantsBeck's Depression Inventoryepidemiologynontreatment-resistant depressiontreatment-resistant depression

Identifiers

PMID38464636
PMCPMC10920685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.