Evidence map›Paper›PMID 38464428›Full record

ArticleTransplantation direct2024

Single-center Outcomes After Liver Transplantation With SARS-CoV-2-Positive Donors: An Argument for Increased Utilization.

Ashton A Connor, Max W Adelman, Constance M Mobley, Mozhgon Moaddab, Alexandra J Erhardt, David E Hsu, Elizabeth W Brombosz, Mansi Sanghvi, Yee Lee Cheah, Caroline J Simon and 16 more

Abstract read
In one paragraph

Article in Transplantation direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ashton A ConnorDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-7596-3771
Max W AdelmanDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-9277-6046
Constance M MobleyDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0003-3925-4975
Mozhgon MoaddabJC Walter Jr Transplant Center, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-4839-4358
Alexandra J ErhardtDepartment of Surgery, Houston Methodist Hospital, Houston, TX.
David E HsuCenter for Health Data Science and Analytics, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-8137-0171
Elizabeth W BromboszDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-1734-5959
Mansi SanghviDepartment of Surgery, Houston Methodist Hospital, Houston, TX.
Yee Lee CheahDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-6695-4339
Caroline J SimonDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0009-0003-0546-439X
Mark J HobeikaDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-7444-7097
Ashish S SahariaDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0001-5366-8432
David W VictorJC Walter Jr Transplant Center, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0003-1414-3128
Sudha KodaliJC Walter Jr Transplant Center, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-2816-9647
Tamneet BasraJC Walter Jr Transplant Center, Houston Methodist Hospital, Houston, TX.
Edward A GravissDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0003-1024-5813
Duc T NguyenDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-5059-4404
Ahmed ElsaieyDepartment of Surgery, Houston Methodist Hospital, Houston, TX.
Linda W MooreDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0003-2519-5150
Masayuki NigoDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0003-4898-1808
Ashley L DrewsDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, TX.
Kevin A GrimesDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-6190-0497
Cesar A AriasDivision of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0001-9054-9774
Xian C LiDepartment of Surgery, Houston Methodist Hospital, Houston, TX.ORCID https://orcid.org/0000-0002-5981-2762
A Osama GaberDepartment of Surgery, Houston Methodist Hospital, Houston, TX.
R Mark GhobrialDepartment of Surgery, Houston Methodist Hospital, Houston, TX.

Funding

Deep Learning Based Pharmacokinetic Model for VancomycinR01AI175699 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI NIGO, MASAYUKI · 2023 to 2025
$2.4M
NIAID NIH HHS R01 AI175699
6 · The paper itself

Abstract

Background: The COVID-19 pandemic has led to an increase in SARS-CoV-2-test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be balanced against the potential risk of donor-derived viral transmission. Although emerging evidence suggests that the use of COVID-19-positive donor organs may be safe, granular series thoroughly evaluating safety are still needed. Results of 29 consecutive LTs from COVID-19-positive donors at a single center are presented here. Methods: A retrospective cohort study of LT recipients between April 2020 and December 2022 was conducted. Differences between recipients of COVID-19-positive (n = 29 total; 25 index, 4 redo) and COVID-19-negative (n = 472 total; 454 index, 18 redo) deceased donor liver grafts were compared. Results: COVID-19-positive donors were significantly younger ( Conclusions: The utilization of liver grafts from COVID-19-positive donors was not associated with a decreased overall survival of recipients. There was no suggestion of viral transmission from donor to recipient. The results from this large single-center study suggest that COVID-19-positive donors may be used safely to expand the deceased donor pool.

Identifiers

PMID38464428
PMCPMC10923316

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.