Evidence map›Paper›PMID 38464379›Full record

ArticleWorld journal of diabetes2024

Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats

Huai-Jie Wang, Li-Bin Zhang, Si-Peng Sun, Qing-Tao Yan, Zhi-Qin Gao, Fang-Ming Fu, Mei-Hua Qu

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Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Huai-Jie WangTranslational Medical Center, Weifang Second People's Hospital, Weifang 261041, Shandong Province, China.
Li-Bin ZhangDepartment of Endocrinology, Weifang Second People's Hospital, Weifang 261041, Shandong Province, China.
Si-Peng SunTranslational Medical Center, Weifang Second People's Hospital, Weifang 261041, Shandong Province, China.
Qing-Tao YanDepartment of Pediatric Surgery, Weifang People's Hospital, Weifang 261041, Shandong Province, China.
Zhi-Qin GaoSchool of Bioscience and Technology, Weifang Medical University, Weifang 261053, Shandong Province, China.
Fang-Ming FuDepartment of Endocrinology, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China.
Mei-Hua QuTranslational Medical Center, Weifang Second People's Hospital, Weifang 261041, Shandong Province, China. qumeihua2016@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is often accompanied by impaired glucose utilization in the brain, leading to oxidative stress, neuronal cell injury and infla-mmation. Previous studies have shown that duodenal jejunal bypass (DJB) surgery significantly improves brain glucose metabolism in T2DM rats, the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain unclear.

aimTo investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM rats.

methodsA T2DM rat model was induced

resultsQuantitative proteomics analysis showed significant differences in proteins related to oxidative stress, inflammation, and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery, compared to the T2DM-Sham groups of rats. Oxidative stress-related proteins (glucagon-like peptide 1 receptor, Nrf2, and HO-1) were significantly increased (

conclusionDJB surgery improve oxidative stress and inflammation in the hypothalamus of T2DM rats and reduce neuronal cell injury by activating the glucagon-like peptide 1 receptor-mediated Nrf2/HO-1 signaling pathway.

Indexed as

Duodenal jejunal bypass surgeryHypothalamic injuryInflammatoryNeuron apoptosisOxidative stressType 2 diabetes mellitus

Identifiers

PMID38464379
PMCPMC10921169

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