ArticlebioRxiv : the preprint server for biology2024
Designed mosaic nanoparticles enhance cross-reactive immune responses in mice.
Eric Wang, Alexander A Cohen, Luis F Caldera, Jennifer R Keeffe, Annie V Rorick, Yusuf M Aida, Priyanthi N P Gnanapragasam, Pamela J Bjorkman, Arup K Chakraborty
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 3 countries.
Eric WangInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
Alexander A CohenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Luis F CalderaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Jennifer R KeeffeDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Annie V RorickDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Yusuf M AidaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Priyanthi N P GnanapragasamDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Pamela J BjorkmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Arup K ChakrabortyInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
California Institute of Technology · USMassachusetts Institute of Technology · USRagon Institute of MGH, MIT and Harvard · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MThe longevity and nature of the anti-SARS-CoV-2 cellular and humoral immune responsesP01AI165075 · NIAID · ROCKEFELLER UNIVERSITY · PI BIENIASZ, PAUL D., BJORKMAN, PAMELA J · 2022 to 2023
$10.7MCombinatorial and computational design of bnAb mRNA vaccines for HIVR61AI161805 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANDERSON, DANIEL G · 2021 to 2023
$2.1MNIAID NIH HHS P01 AI165075NIAID NIH HHS R61 AI161805NIAID NIH HHS U19 AI057229Wellcome Trust
6 · The paper itselfAbstract
1Using computational methods, we designed 60-mer nanoparticles displaying SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs) by (
Indexed as
antibodycomputational methodsnanoparticleprotein designRBDsarbecovirusSARS-CoV-2vaccination
Identifiers
PMID38464322
PMCPMC10925254
OpenAlexW4392291657
What OpenQuestion holds
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LicenceCC BY
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