ArticlemedRxiv : the preprint server for health sciences2024
Association analysis between an epigenetic alcohol risk score and blood pressure.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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38 authors at 13 institutions in 5 countries.
Helena BuiPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Amena KeshawarzPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mengyao WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Mikyeong LeeEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-6109-662X
Lisha LinDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Kira S BirdittSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-6969-6478
Annette PetersInstitute of Epidemiology, Helmholtz Munich, German Research Center for Environmental Health, German.ORCID 0000-0001-6645-0985
Christian GiegerGerman Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Thomas DelerueResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Munich, German Research Center for Environmental Health, Bavaria, Germany.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Xiuqing GuoThe Institute for Translational Genomics and Populations, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jie YaoThe Institute for Translational Genomics and Populations, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jerome I RotterThe Institute for Translational Genomics and Populations, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Yi LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Xue LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Dan LiuPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Juliana F TavaresPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Gökhan PehlivanPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Monique M B BretelerPopulation Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID 0000-0002-0626-9305
Irma KarabegovicDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Carolina Ochoa-RosalesDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Trudy VoortmanDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-9476-7143
Joyce B J van MeursDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Mohamed Kamal NasrInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Marcus DörrGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine, Greifswald, Germany.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID 0000-0003-4911-5290
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Melanie WaldenbergerGerman Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-3575-5468
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jiantao MaGerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Chunyu LiuFramingham Heart Study, Framingham, MA, USA.
University of Michigan · USNational Institutes of Health · USBoston University · USErasmus MC · NLGerman Center for Neurodegenerative Diseases · DEHelmholtz Zentrum München · DEUCLA Medical Center · USUniversitätsmedizin Greifswald · DECenter for Environmental Health · USMedical University of Białystok · PLTufts University · USUniversity of Bonn · DEUniversity of Concepción · CL
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MGenomic Predictors of Arteriosclerosis in HypertensivesR01HL087660 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2007 to 2009
$5.1MSTUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0MTO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5MIntramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES043012Intramural NIH HHS Z01 ES049030NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01 HL141292NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U10 HL054457NIAAA NIH HHS R01 AA028263NIA NIH HHS R01 AG060110NIA NIH HHS U01 AG009740NIDDK NIH HHS P30 DK063491
Abstract
Background: Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. Results: We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( Conclusions: Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.
Indexed as
alcoholblood pressureDNA methylationepigenetic risk scorehypertension
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