In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Johanna K S TiemannUniversity of Copenhagen, Linderstrøm-Lang Centre for Protein Science, Copenhagen N., Denmark, and Novozymes A/S, Lyngby, Denmark.ORCID 0000-0001-7551-6245 Aleksandra PanfilovaUniversity of Copenhagen, Linderstrøm-Lang Centre for Protein Science, Copenhagen N., Denmark.
Jens MeilerVanderbilt University, Center for Structural Biology, Nashville, Tennessee, USA, and Leipzig University Medical School, Institute for Drug Discovery, Leipzig, Germany.ORCID 0000-0001-8945-193X Peter W HildebrandLeipzig University, Institute for Medical Physics and Biophysics, Leipzig, Germany, and Charité Universitätsmedizin Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-0063-1104 Amelie SteinUniversity of Copenhagen, Linderstrøm-Lang Centre for Protein Science, Copenhagen N., Denmark.ORCID 0000-0002-5862-1681 René StaritzbichlerLeipzig University, Institute for Medical Physics and Biophysics, Leipzig, Germany.ORCID 0000-0002-6719-2997 Funding
Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5MCerebrovascular involvement in Alzheimer's Disease: PAR4 AntagonismRF1AG068623 · NIA · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, MEILER, JENS · 2021 to 2021
$2.2MStructural Determinants of Allosteric Modulation of Brain GPCRsR01DA046138 · NIDA · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2019 to 2023
$2.0MMechanistic insights into Variants of Uncertain Significance (VUS) using novel EGFR variants as a paradigmR01CA227833 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LOVLY, CHRISTINE M., MEILER, JENS · 2019 to 2023
$1.7MCerebrovascular involvement in Alzheimer's Disease: PAR4 AntagonismR01AG068623 · NIA · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, MEILER, JENS · 2024 to 2025
$1.4MPersonalized Structural Biology: Enabling Exome Interpretation in Undiagnosed DiseasesR01LM013434 · NLM · VANDERBILT UNIVERSITY · PI CAPRA, JOHN ANTHONY, MEILER, JENS · 2021 to 2024
$1.4MGPU-Accelerated Parallel Computer for Life Sciences ResearchS10OD032234 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2022 to 2022
$600kParallel Computer with High Memory NodesS10OD016216 · OD · VANDERBILT UNIVERSITY · PI PISTON, DAVID W · 2013 to 2013
$598kGPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225kNCI NIH HHS R01 CA227833NHLBI NIH HHS R01 HL122010NIA NIH HHS R01 AG068623NIA NIH HHS RF1 AG068623NIDA NIH HHS R01 DA046138NIH HHS S10 OD016216NIH HHS S10 OD020154NIH HHS S10 OD032234NLM NIH HHS R01 LM013434
6 · The paper itselfAbstract
The possible effects of mutations on stability and function of a protein can only be understood in the context of protein 3D structure. The MutationExplorer webserver maps sequence changes onto protein structures and allows users to study variation by inputting sequence changes. As the user enters variants, the 3D model evolves, and estimated changes in energy are highlighted. In addition to a basic per-residue input format, MutationExplorer can also upload an entire replacement sequence. Previously the purview of desktop applications, such an upload can back-mutate PDB structures to wildtype sequence in a single step. Another supported variation source is human single nucelotide polymorphisms (SNPs), genomic coordinates input in VCF format.
Identifiers
PMID38464310
PMCPMC10925206
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