Evidence map›Paper›PMID 38464274›Full record

ArticlebioRxiv : the preprint server for biology2024

Kir6.2-K

Nicholas J Constantino, Caitlin M Carroll, Holden C Williams, Carla M Yuede, Patrick W Sheehan, J Andy Snipes, Erik S Musiek, Lance A Johnson, Shannon L Macauley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicholas J Constantino
Caitlin M CarrollORCID 0000-0003-1572-7360
Holden C Williams
Carla M YuedeORCID 0000-0001-6362-4767
Patrick W Sheehan
J Andy Snipes
Erik S MusiekORCID 0000-0002-8873-0360
Lance A Johnson
Shannon L Macauley
University of Kentucky · USWashington University in St. Louis · USWake Forest University · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Sustained eIF5A hypusination at the core of brain metabolic dysfunction in TDP-43 proteinopathiesP20GM148326 · NIGMS · UNIVERSITY OF KENTUCKY · PI Caroline Elyse Geisler · 2023 to 2026
$10.6M
The metabolic interplay of sleep and Alzheimer's diseaseR01AG068330 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MACAULEY-RAMBACH, SHANNON L · 2020 to 2024
$3.5M
NIA NIH HHS R01 AG068330NIDDK NIH HHS P30 DK056341NIGMS NIH HHS P20 GM148326
6 · The paper itself

Abstract

Metabolism plays an important role in the maintenance of vigilance states (e.g. wake, NREM, and REM). Brain lactate fluctuations are a biomarker of sleep. Increased interstitial fluid (ISF) lactate levels are necessary for arousal and wake-associated behaviors, while decreased ISF lactate is required for sleep. ATP-sensitive potassium (K Highlights: Glycolytic flux is necessary for neurotransmitter synthesis. In its absence, neuronal activity is compromised causing changes in arousal and vigilance states despite sufficient energy availability. With Kir6.2-K

Identifiers

PMID38464274
PMCPMC10925108
OpenAlexW4392243925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.