Evidence map›Paper›PMID 38464265›Full record

ArticlebioRxiv : the preprint server for biology2024

Binding Site Maturation Modulated by Molecular Density Underlies Ndc80 Binding to Kinetochore Receptor CENP-T.

Ekaterina V Tarasovetc, Gunter B Sissoko, Aleksandr Maiorov, Anna S Mukhina, Fazoil I Ataullakhanov, Iain M Cheeseman, Ekaterina L Grishchuk

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ekaterina V TarasovetcDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
Gunter B SissokoWhitehead Institute for Biomedical Research; Cambridge, MA 02142, USA.
Aleksandr MaiorovDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
Anna S MukhinaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
Fazoil I AtaullakhanovDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
Iain M CheesemanWhitehead Institute for Biomedical Research; Cambridge, MA 02142, USA.
Ekaterina L GrishchukDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
University of Pennsylvania · USWhitehead Institute for Biomedical Research · USLomonosov Moscow State University · RUMoscow Institute of Physics and Technology · RU

Funding

Molecular Analysis of Kinetochore FunctionR35GM126930 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Iain McPherson Cheeseman · 2018 to 2026
$7.0M
Biomechanics of molecular machines and multiscale non-linear systemsR35GM141747 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ekaterina L Grishchuk · 2021 to 2026
$3.7M
NIGMS NIH HHS R35 GM126930NIGMS NIH HHS R35 GM141747
6 · The paper itself

Abstract

Macromolecular assembly depends on tightly regulated pairwise binding interactions that are selectively favored at assembly sites while being disfavored in the soluble phase. This selective control can arise due to molecular density-enhanced binding, as recently found for the kinetochore scaffold protein CENP-T. When clustered, CENP-T recruits markedly more Ndc80 complexes than its monomeric counterpart, but the underlying molecular basis remains elusive. Here, we use quantitative

Indexed as

binding site maturationBiochemistryBiological SciencesBiophysics and Computational Biologyhigher-order assemblykinetic barrierkinetochoresingle-molecule binding assay

Identifiers

PMID38464265
PMCPMC10925139
OpenAlexW4392201188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.