Evidence map›Paper›PMID 38464255›Full record

ArticlemedRxiv : the preprint server for health sciences2025

T cell and autoantibody profiling for primary immune regulatory disorders.

Emily M Harris, Sarah Chamseddine, Anne Chu, Leetah Senkpeil, Matthew Nikiciuk, Aleksandra Bourdine, Logan Magin, Amer Al-Musa, Brian Woods, Elif Ozdogan and 18 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 2 institutions in 1 country.

Emily M HarrisDana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8583-6939
Sarah ChamseddineDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0001-7627-0387
Anne ChuDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Leetah SenkpeilDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Matthew NikiciukDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Aleksandra BourdineDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Logan MaginDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Amer Al-MusaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Brian WoodsDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Elif OzdoganSengenics, Kuala Lumpur, Malaysia.
Sarife SakerDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
David P Hoytema van KonijnenburgDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Christina S K YeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ryan W NelsonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Pui LeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Olha HalyabarDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rebecca C HaleDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Megan Day-LewisDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A HendersonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Alan A NguyenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Megan ElkinsDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Toshiro K OhsumiDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Maria Gutierrez-ArcelusDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Janique M PeyperSengenics, Kuala Lumpur, Malaysia.
Craig D PlattDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rachael F GraceDana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Brenna LaBereDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Janet ChouDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4610-2657
Boston Children's Hospital · USHarvard University · US

Funding

PATHOPHYSIOLOGY OF HUMAN BLOOD CELLST32HL007574 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Daniel Evan Bauer · 1985 to 2026
$18.4M
MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
The Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9M
Mechanisms of pediatric overweight and obesity underlying susceptibility to multisystem inflammatory syndrome in children (MIS-C)R01DK130465 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI CHOU, JANET · 2021 to 2023
$1.4M
NHLBI NIH HHS T32 HL007574NIAID NIH HHS T32 AI007512NICHD NIH HHS K12 HD052896NIDDK NIH HHS R01 DK130465
6 · The paper itself

Abstract

Background: Limited clinical tools exist for characterizing primary immune regulatory disorders (PIRD), which are often diagnoses of exclusion. Increased CD4 Objective: To develop a diagnostic approach that combines measurements of cellular and serologic autoimmunity. Methods: We recruited 71 controls and 101 pediatric patients with PIRD with autoimmunity. Flow cytometry was used to measure CD4 Results: We found that 27.7% of patients had increased percentages of CD4 Conclusion: By integrating CD4

Indexed as

autoantibodiesautoimmunityprimary immune regulatory disordersT follicular helper cells

Identifiers

PMID38464255
PMCPMC10925364
OpenAlexW4392188116

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.