Evidence map›Paper›PMID 38464225›Full record

ArticlebioRxiv : the preprint server for biology2024

Rare and Common Variants Associated with Alcohol Consumption Identify a Conserved Molecular Network.

Brittany S Leger, John J Meredith, Trey Ideker, Sandra Sanchez-Roige, Abraham A Palmer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Brittany S LegerProgram in Biomedical Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8467-5472
John J MeredithDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6622-6414
Trey IdekerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1708-8454
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6137-5699
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3634-0747

Funding

Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across SpeciesR01AA029688 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hae Kyung Im, Abraham A Palmer · 2022 to 2026
$3.1M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
NIAAA NIH HHS R01 AA029688NIDA NIH HHS DP1 DA054394NIGMS NIH HHS T32 GM008666
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified hundreds of common variants associated with alcohol consumption. In contrast, rare variants have only begun to be studied for their role in alcohol consumption. No studies have examined whether common and rare variants implicate the same genes and molecular networks. To address this knowledge gap, we used publicly available alcohol consumption GWAS summary statistics (GSCAN, N=666,978) and whole exome sequencing data (Genebass, N=393,099) to identify a set of common and rare variants for alcohol consumption. Gene-based analysis of each dataset have implicated 294 (common variants) and 35 (rare variants) genes, including ethanol metabolizing genes

Identifiers

PMID38464225
PMCPMC10925118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.