Evidence map›Paper›PMID 38464220›Full record

ArticlebioRxiv : the preprint server for biology2024

Bicyclic pyrrolidine inhibitors of

Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller, Amit Sharma, Eamon Comer, Stuart L Schreiber, Bruno Melillo and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Chloe C EnceCalibr at Scripps Research, La Jolla, CA 92037, USA.
Taher UddinDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Julien BorrelChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Payal MittalMolecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Han XieCalibr at Scripps Research, La Jolla, CA 92037, USA.
Jochen ZollerChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Amit SharmaMolecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Eamon ComerChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Stuart L SchreiberChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Bruno MelilloChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63130, USA.
Arnab K ChatterjeeCalibr at Scripps Research, La Jolla, CA 92037, USA.
Broad Institute · USScripps Institution of Oceanography · USInternational Centre for Genetic Engineering and Biotechnology · INWashington University in St. Louis · US

Funding

Exploiting Diversity-Oriented Chemical Synthesis for Combating Chronic Parasitic InfectionR01AI143857 · NIAID · WASHINGTON UNIVERSITY · PI Arnab Kumar Chatterjee, L. David Sibley · 2020 to 2026
$7.9M
NIAID NIH HHS R01 AI143857
6 · The paper itself

Abstract

Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth inhibition

Indexed as

anti-infectivecentral nervous system infectionsmall molecule inhibitortoxoplasmosis

Identifiers

PMID38464220
PMCPMC10925249
OpenAlexW4392281964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.