Evidence map›Paper›PMID 38464212›Full record

ArticlebioRxiv : the preprint server for biology2024

Discovering Genetic Modulators of the Protein Homeostasis System through Multilevel Analysis.

Vishal Sarsani, Berent Aldikacti, Tingting Zhao, Shai He, Peter Chien, Patrick Flaherty

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vishal SarsaniDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, 01002, Massachusetts, USA.ORCID 0000-0002-9272-3438
Berent AldikactiDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, 01002, Massachusetts, USA.
Tingting ZhaoDepartment of Information Systems and Analytics, Bryant University, Smithfield, 02917, RI, USA.
Shai HeDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, 01002, Massachusetts, USA.
Peter ChienDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, 01002, Massachusetts, USA.
Patrick FlahertyDepartment of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, 01002, Massachusetts, USA.ORCID 0000-0001-6097-6572
Amherst College · USUniversity of Massachusetts Amherst · USBryant University · US

Funding

Learning Conditionally Essential Genetic Networks in the Protein Homeostasis System R01GM135931 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FLAHERTY, PATRICK · 2019 to 2021
$693k
NIGMS NIH HHS R01 GM135931
6 · The paper itself

Abstract

Every protein progresses through a natural lifecycle from birth to maturation to death; this process is coordinated by the protein homeostasis system. Environmental or physiological conditions trigger pathways that maintain the homeostasis of the proteome. An open question is how these pathways are modulated to respond to the many stresses that an organism encounters during its lifetime. To address this question, we tested how the fitness landscape changes in response to environmental and genetic perturbations using directed and massively parallel transposon mutagenesis in

Indexed as

conditionally essential networksfitnessproteotoxic stresstransposon mutagenesis

Identifiers

PMID38464212
PMCPMC10925187
OpenAlexW4392365347

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.