Evidence map›Paper›PMID 38464209›Full record

ArticlebioRxiv : the preprint server for biology2024

Activated STING in the thymus alters T cell development and selection leading to autoimmunity.

Zimu Deng, Christopher S Law, Santosh Kurra, Noa Simchoni, Anthony K Shum

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zimu DengDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143.
Christopher S LawDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143.
Santosh KurraDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143.
Noa SimchoniDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143.
Anthony K ShumDepartment of Medicine, University of California San Francisco, San Francisco, CA 94143.ORCID 0000-0001-5139-4802
University of California, San Francisco · US

Funding

Unraveling the molecular mechanisms of impaired central tolerance in COPA syndromeR01AI168299 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anthony Shum · 2022 to 2026
$3.3M
Academic Rheumatology and Clinical ImmunologyT32AR079068 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany, JULIE ZIKHERMAN · 2021 to 2026
$2.5M
Defining the Role of Thymic Tolerance in the Pathogenesis of the COPA syndromeR01AI137249 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHUM, ANTHONY · 2018 to 2022
$2.4M
NIAID NIH HHS R01 AI137249NIAID NIH HHS R01 AI168299NIAMS NIH HHS T32 AR079068
6 · The paper itself

Abstract

Classifying systemic inflammatory disorders as autoinflammatory or autoimmune provides insight into disease pathogenesis and whether treatment should target innate molecules and their signaling pathways or the adaptive immune response. COPA syndrome is a monogenic disorder of immune dysregulation that leads to interstitial lung disease and high-titer autoantibodies. Studies show constitutive activation of the innate immune molecule STING is centrally involved in disease. However, the mechanisms by which STING results in loss of T cell tolerance and autoimmunity in COPA syndrome or more common autoimmune diseases is not understood. Using

Identifiers

PMID38464209
PMCPMC10925148
OpenAlexW4391981647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.