Evidence map›Paper›PMID 38464201›Full record

ArticleResearch square2024

Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes.

Elisa Bovo, Jaroslava Seflova, Seth L Robia, Aleksey V Zima

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisa BovoLoyola University Chicago, Stritch School of Medicine.
Jaroslava SeflovaLoyola University Chicago, Stritch School of Medicine.
Seth L RobiaLoyola University Chicago, Stritch School of Medicine.
Aleksey V ZimaLoyola University Chicago, Stritch School of Medicine.
Loyola University Chicago · US

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
New mechanisms of SERCA2a regulation: role of luminal calciumR01HL151990 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2021 to 2024
$1.7M
NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL151990
6 · The paper itself

Abstract

Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic changes cause an abnormality in cardiac Ca

Indexed as

Ca2+ signalingheartmethylglyoxalNa+/Ca2+ exchangerNa+ homeostasisNa+ pumpsarcoplasmic reticulum

Identifiers

PMID38464201
PMCPMC10925417
OpenAlexW4392364400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.