Evidence map›Paper›PMID 38464199›Full record

ArticlebioRxiv : the preprint server for biology2024

Targeting Iron - Respiratory Reciprocity Promotes Bacterial Death.

Mohammad Sharifian Gh, Fatemeh Norouzi, Mirco Sorci, Tanweer S Zaid, Gerald B Pier, Alecia Achimovich, George M Ongwae, Binyong Liang, Margaret Ryan, Michael Lemke and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Mohammad Sharifian GhDepartment of Cell Biology, University of Virginia, Charlottesville VA, USA.ORCID 0000-0003-3867-1611
Fatemeh NorouziDepartment of Cell Biology, University of Virginia, Charlottesville VA, USA.ORCID 0000-0002-2332-0125
Mirco SorciHoward P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy NY, USA.ORCID 0000-0001-6053-6702
Tanweer S ZaidDivision of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA.ORCID 0000-0002-9112-2331
Gerald B PierDivision of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA.
Alecia AchimovichDepartment of Chemistry, University of Virginia, Charlottesville VA, USA.
George M OngwaeDepartment of Chemistry, University of Virginia, Charlottesville VA, USA.ORCID 0000-0001-7380-2301
Binyong LiangDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville VA, USA.
Margaret RyanDepartment of Cell Biology, University of Virginia, Charlottesville VA, USA.
Michael LemkeDepartment of Pharmacology, University of Virginia, Charlottesville VA, USA.
Georges BelfortHoward P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy NY, USA.ORCID 0000-0002-7314-422X
Mihaela GadjevaDivision of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA.ORCID 0000-0002-9014-386X
Andreas GahlmannDepartment of Chemistry, University of Virginia, Charlottesville VA, USA.ORCID 0000-0001-7521-6787
Marcos M PiresDepartment of Chemistry, University of Virginia, Charlottesville VA, USA.ORCID 0000-0002-5676-0725
Henrietta VenterSansom Institute for Health Research, University of South Australia, Adelaide, Australia.ORCID 0000-0001-5569-7755
Thurl E HarrisDepartment of Pharmacology, University of Virginia, Charlottesville VA, USA.ORCID 0000-0003-1742-6043
Gordon W LaurieDepartment of Cell Biology, University of Virginia, Charlottesville VA, USA.ORCID 0000-0002-5311-2650
University of Virginia · USBrigham and Women's Hospital · USRensselaer Polytechnic Institute · USUniversity of South Australia · AU

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Tear Protein Microbial RegulationR01EY026171 · NEI · UNIVERSITY OF VIRGINIA · PI LAURIE, GORDON WILLIAM · 2016 to 2025
$3.6M
Lacritin Regulation of Homeostasis and Ocular Surface HealthR01EY032956 · NEI · UNIVERSITY OF VIRGINIA · PI LAURIE, GORDON WILLIAM · 2021 to 2025
$2.4M
NCI NIH HHS P30 CA044579NEI NIH HHS R01 EY026171NEI NIH HHS R01 EY032956
6 · The paper itself

Abstract

Discovering new bacterial signaling pathways offers unique antibiotic strategies. Here, through an unbiased resistance screen of 3,884 gene knockout strains, we uncovered a previously unknown non-lytic bactericidal mechanism that sequentially couples three transporters and downstream transcription to lethally suppress respiration of the highly virulent

Identifiers

PMID38464199
PMCPMC10925246
OpenAlexW4392351734

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.