ArticleResearch square2024
The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain.
Lindsey A Fitzsimons, Larissa Staurengo-Ferrari, Oliver Bogen, Dioneia Araldi, Ivan J M Bonet, Ethan E Jordan, Jon D Levine, Kerry L Tucker
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 2 countries.
Lindsey A FitzsimonsDept. of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, United States.ORCID 0000-0002-1949-6849 Larissa Staurengo-FerrariDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco, United States.
Oliver BogenDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco, United States.
Dioneia AraldiDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco, United States.
Ivan J M BonetDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco, United States.
Ethan E JordanDept. of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, United States.
Jon D LevineDepartment of Oral and Maxillofacial Surgery, UCSF Pain and Addiction Research Center, University of California San Francisco, San Francisco, United States.
Kerry L TuckerDept. of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, United States.ORCID 0000-0001-7671-8690 University of California, San Francisco · USPhiladelphia College of Osteopathic Medicine · US
Funding
Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9MChronic Chemotherapy Peripheral Neuropathy: Role of Neuroplasticity and StressR01CA250017 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.3MHyaluronan signaling to nociceptors in inflammatory painR01AR075334 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2019 to 2023
$3.0MRole of Nociceptor Primary Cilia in Inflammatory and Neuropathic PainR21NS130249 · NINDS · UNIVERSITY OF NEW ENGLAND · PI TUCKER, KERRY L · 2022 to 2022
$391kNCI NIH HHS R01 CA250017NIAMS NIH HHS R01 AR075334NIGMS NIH HHS P20 GM103643NINDS NIH HHS R21 NS130249
6 · The paper itselfAbstract
The primary cilium, a 1-3 μm long hair-like structure protruding from the surface of almost all cells in the vertebrate body, is critical for neuronal development and also functions in the adult. As the migratory neural crest settles into dorsal root ganglia (DRG) sensory neurons elaborate a single primary cilium at their soma that is maintained into adult stages. While it is not known if primary cilia are expressed in nociceptors, or their potential function in the mature DRG neuron, recent studies have shown a role for Hedgehog, whose signaling demonstrates a dependence on primary cilia, in nociceptor sensitization. Here we report the expression of primary cilia in rat and mouse nociceptors, where they modulate mechanical nociceptive threshold, and contribute to inflammatory and neuropathic pain. When siRNA targeting
Indexed as
Chemotherapy-induced NeuropathyCyclopamineHedgehogHyperalgesiaInflammationNociceptorPaclitaxelPainPGE2Primary CiliumsiRNASonic Hedgehog
Identifiers
PMID38464172
PMCPMC10925437
OpenAlexW4392167465
What OpenQuestion holds
Textmetadata
LicenceCC BY
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