Evidence map›Paper›PMID 38464150›Full record

ArticlebioRxiv : the preprint server for biology2024

Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice.

Qijun Zhang, Evan R Hutchison, Calvin Pan, Matthew F Warren, Mark P Keller, Alan D Attie, Aldons J Lusis, Federico E Rey

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qijun ZhangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Evan R HutchisonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Calvin PanDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Matthew F WarrenDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Alan D AttieDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Aldons J LusisDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Federico E ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of California, Los Angeles · US

Funding

TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
Genetic Control of Metabolic Flux in Response to DietRC2DK125961 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2020 to 2024
$8.1M
Establishing mechanistic links between the gut microbiome and atherosclerosisR01HL148577 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2020 to 2023
$2.6M
Gut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL144651NHLBI NIH HHS R01 HL148577NIDDK NIH HHS RC2 DK125961NIDDK NIH HHS T32 DK007665
6 · The paper itself

Abstract

The molecular basis for how host genetic variation impacts gut microbial community and bacterial metabolic niches remain largely unknown. We leveraged 90 inbred hyperlipidemic mouse strains from the Hybrid Mouse Diversity Panel (HMDP), previously studied for a variety of cardio-metabolic traits. Metagenomic analysis of cecal DNA followed by genome-wide association analysis identified genomic loci that were associated with microbial enterotypes in the gut. Among these we detected a genetic locus surrounding multiple amylase genes that was associated with abundances of Firmicutes (

Identifiers

PMID38464150
PMCPMC10925268
OpenAlexW4392343328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.