Evidence map›Paper›PMID 38464118›Full record

ArticlebioRxiv : the preprint server for biology2024

NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation.

Paige E Anton, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCullough

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Paige E AntonDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-6720-7098
Prashant NagpalSachi Bio, Louisville, CO.ORCID 0000-0002-7966-2554
Julie MorenoDepartment of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.ORCID 0000-0002-9618-2712
Matthew A BurchillGI and Liver Innate Immune Program, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0003-3118-2962
Anushree ChatterjeeSachi Bio, Louisville, CO.ORCID 0000-0002-8389-9917
Nicolas BusquetAnimal Behavior & In Vivo Neurophysiology Core, NeuroTechnology Center, University of Colorado Anschutz Medical Campus, Aurora, CO.
Michael MeschesAnimal Behavior & In Vivo Neurophysiology Core, NeuroTechnology Center, University of Colorado Anschutz Medical Campus, Aurora, CO.
Elizabeth J KovacsAlcohol Research Program, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0002-9459-9928
Rebecca L McCulloughDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-5341-7326
University of Colorado Anschutz Medical Campus · USColorado State University · USVeterans Health Administration · US

Funding

Aging, macrophage mediators, and burn trauma: SupplementR01AG018859 · NIA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2001 to 2024
$7.6M
Neuroinflammatory GeroMiRs and Alcohol: Defining Mechanisms of ADRDR01AA030741 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI Rebecca LeAnne Smathers McCullough · 2024 to 2026
$1.4M
Training in Molecular and Systems ToxicologyT32ES029074 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI Jared Michael Brown · 2019 to 2026
$1.1M
Inflammaging and ADRD: Investigating the Role of Complement and Alcohol.R00AA025386 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI SMATHERS MCCULLOUGH, REBECCA LEANNE · 2018 to 2020
$993k
Alcohol and Lung Immunity in the AgedR21AA026295 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2018 to 2019
$408k
The Neuroinflammatory Impact of Binge Ethanol Exposure in Aged Mice: A Role for NLRP3.F31AA030213 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI ANTON, PAIGE E · 2022 to 2023
$63k
NIAAA NIH HHS F31 AA030213NIAAA NIH HHS R00 AA025386NIAAA NIH HHS R01 AA030741NIAAA NIH HHS R21 AA026295NIA NIH HHS R01 AG018859NIEHS NIH HHS T32 ES029074
6 · The paper itself

Abstract

Binge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened activation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Nod like receptor 3 (NLRP3) mediate microglia activation and associated neuronal injury. Our group, and others, have implicated hippocampal-resident microglia as key producers of inflammatory mediators, yet the link between inflammation and neurodegeneration has not been established in models of binge ethanol exposure and advanced age. Here, we report binge ethanol increased the proportion of NLRP3

Indexed as

advanced agingalcoholmicroglianeurodegenerationNLRP3 inflammasome

Identifiers

PMID38464118
PMCPMC10925165
OpenAlexW4392344469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.