ArticleResearch square2024
The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury.
Open access · greenAbstract readPreprint
In one paragraph
Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
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Corrections and comments
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Authors and funding
29 authors at 8 institutions in 2 countries.
Wei RuanDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.ORCID 0000-0002-2718-7923
Tao LiDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Jaewoong LeeDepartment of Anesthesiology, Yale University School of Medicine, New Haven, CT, 06510, USA.
In Hyuk BangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Wankun DengCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Xinxin MaDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Seung-Hee YooDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.ORCID 0000-0002-9930-560X
Boyun KimDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Jiwen LiDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Xiaoyi YuanDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.ORCID 0000-0002-2898-6495
Yu A AnDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Yin-Ying WangCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Yafen LiangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Matthew DebergeDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Dongze ZhangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Zhen ZhouDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Yanyu WangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Josh GorhamDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-5969-4690
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0002-9082-3566
Christine E SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0001-6380-1209
Sary F ArankiDepartment of Surgery, Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Ragini NairDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Lei LiInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, 518055, China.ORCID 0000-0003-3924-2544
Jagat NarulaWeatherhead PET Center for Preventing and Reversing Atherosclerosis, Division of Cardiology, Department of Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Memorial Hermann Hospital, Houston, TX, 77030, USA.
Zhongming ZhaoCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID 0000-0002-3477-0914
Alemayehu G AbebeDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.ORCID 0000-0002-9328-4692
Jochen Daniel MuehlschlegelDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, 21287, USA.
Kuang-Lei TsaiDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Holger K EltzschigDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.ORCID 0000-0002-5676-6473
The University of Texas Health Science Center at Houston · USHarvard University · USBrigham and Women's Hospital · USHarvard University Press · USJohns Hopkins University · USShenzhen Bay Laboratory · CNThe University of Texas MD Anderson Cancer Center · USYale University · US
Funding
Cardiac Exosomes in myocardial Ischemic injuryR01HL150401 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2020 to 2024
$3.3MFunctional Role of HIF-PHDs in ARDSR01HL169519 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Xiaoyi Yuan · 2023 to 2026
$2.7MCircadian Rhythm as a Therapeutic Target for Perioperative CardioprotectionR01HL165748 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, JOCHEN DANIEL MUEHLSCHLEGEL · 2023 to 2026
$2.6MGenetics of gene expression in human left ventricular myocardiumR01HL118266 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2013 to 2017
$2.3MmicroRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2MTargeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress SyndromeR01HL155950 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaoyi Yuan · 2022 to 2026
$2.0MTargeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8MStructural insights into the Argonaute-containing CDK8 complexR01GM143587 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TSAI, KUANG-LEI · 2021 to 2025
$1.7MDynamics of lipid-anchored proteinsR01GM144836 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GORFE, ALEMAYEHU A. · 2022 to 2025
$1.4MResearch Training of Anesthesiology Physician-ScientistsT32GM135118 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Cynthia Ju · 2022 to 2026
$1.1MAdipocyte mitochondrial distress drives the intercommunication between white and brown adipose tissuesK01DK125447 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI AN, YU · 2021 to 2023
$501kLipocalin-2, a mitokine that mediates white to brown fat crosstalkR03DK135783 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AN, YU · 2023 to 2024
$229kNHLBI NIH HHS R01 HL118266NHLBI NIH HHS R01 HL150401NHLBI NIH HHS R01 HL154720NHLBI NIH HHS R01 HL155950NHLBI NIH HHS R01 HL165748NHLBI NIH HHS R01 HL169519NIDDK NIH HHS K01 DK125447NIDDK NIH HHS R01 DK122796NIDDK NIH HHS R03 DK135783NIGMS NIH HHS R01 GM143587NIGMS NIH HHS R01 GM144836NIGMS NIH HHS T32 GM135118
Abstract
Acute myocardial infarction stands as a prominent cause of morbidity and mortality worldwide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.