Evidence map›Paper›PMID 38464061›Full record

ArticleResearch square2024

SM22α deficiency: promoting vascular fibrosis via SRF-SMAD3-mediated activation of

Jianbin Shen, Donghong Ju, Shichao Wu, Jiawei Zhao, Lucynda Pham, Alejandro Ponce, Maozhou Yang, Hui Joyce Li, Kezhong Zhang, Zhe Yang and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jianbin ShenWayne State University School of Medicine.
Donghong JuWayne State University.
Shichao WuWayne State University.
Jiawei ZhaoWayne State University.
Lucynda PhamWayne State University.
Alejandro PonceWayne State University.
Maozhou YangHenry Ford Health System.
Hui Joyce LiUniversity of Massachusetts Chan Medical School.
Kezhong ZhangWayne State University.
Zhe YangWayne State University.
Youming XieWayne State University.
Li LiWayne State University.ORCID 0000-0001-6598-6358
Wayne State University · USHenry Ford Health System · USUniversity of Massachusetts Chan Medical School · US

Funding

The regulatory roles of nuclear SM22 in smooth muscle phenotypic modulationR01HL142956 · NHLBI · WAYNE STATE UNIVERSITY · PI LI, LI · 2018 to 2021
$2.1M
Chromatin Remodeling in Smooth Muscle Myogenesis and Vascular Injury ResponsesR01HL087014 · NHLBI · WAYNE STATE UNIVERSITY · PI LI, LI · 2007 to 2011
$1.9M
GENETIC CONTROL OF SMOOTH MUSCLE GENE EXPRESSIONR01HL058916 · NHLBI · WAYNE STATE UNIVERSITY · PI LI, LI · 1998 to 2002
$850k
NHLBI NIH HHS R01 HL058916NHLBI NIH HHS R01 HL087014NHLBI NIH HHS R01 HL142956
6 · The paper itself

Abstract

Vascular fibrosis, characterized by increased Type I collagen expression, significantly contributes to vascular remodeling. Our previous studies show that disrupting the expression of SM22α (aka SM22, Tagln) induces extensive vascular remodeling following arterial injury, involving oxidative stress, inflammation, and chondrogenesis within the vessel wall. This study aims to investigate the molecular mechanisms underlying the transcription of

Indexed as

Cal1a2SM22/TaglnSmad3SRFtranscriptionvascular fibrosis

Identifiers

PMID38464061
PMCPMC10925461
OpenAlexW4392197051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.