Evidence map›Paper›PMID 38464001›Full record

ArticlebioRxiv : the preprint server for biology2024

Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques.

Xin Tong, Qixin Wang, Wonyeong Jung, Taras M Chicz, Ross Blanc, Lily J Parker, Dan H Barouch, Ryan P McNamara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xin TongRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Qixin WangRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Wonyeong JungRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Taras M ChiczRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Ross BlancRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Lily J ParkerRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Dan H BarouchRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.
Ryan P McNamaraRagon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States.ORCID 0000-0002-8866-3532
Ragon Institute of MGH, MIT and Harvard · USBeth Israel Deaconess Medical Center · US

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Kristian Graugaard Andersen · 2018 to 2026
$32.0M
Technology and Computational CoreP01AI165072 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2021 to 2023
$19.6M
Immunologic Signatures of SARS-CoV-2 Vaccination and DiseaseU01CA260476 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H. · 2020 to 2024
$3.7M
NCI NIH HHS U01 CA260476NIAID NIH HHS P01 AI165072NIAID NIH HHS U19 AI135995
6 · The paper itself

Abstract

Antibodies represent a primary mediator of protection against respiratory viruses such as SARS-CoV-2. Serum neutralizing antibodies (NAbs) are often considered a primary correlate of protection. However, detailed antibody profiles including characterization of antibody functions in different anatomic compartments are not well understood. Here we show that antibody correlates of protection against SARS-CoV-2 challenge are different in systemic versus mucosal compartments in rhesus macaques. In serum, neutralizing antibodies were the strongest correlate of protection and were linked to Spike-specific binding antibodies and other extra-neutralizing antibody functions that create a larger protective network. In contrast, in bronchiolar lavage (BAL), antibody-dependent cellular phagocytosis (ADCP) proved the strongest correlate of protection rather than NAbs. Within BAL, ADCP was linked to mucosal Spike-specific IgG, IgA/secretory IgA, and Fcγ-receptor binding antibodies. Our results support a model in which antibodies with different functions mediate protection at different anatomic sites. The correlation of ADCP and other Fc functional antibody responses with protection in BAL suggests that these antibody responses may be critical for protection against SARS-CoV-2 Omicron challenge in mucosa.

Indexed as

Antibodiescompartment-specific immunitycorrelates of protectioneffector functionnatural killer cellsneutralizationOmicronSARS-CoV-2systems immunologyvaccines

Identifiers

PMID38464001
PMCPMC10925337
OpenAlexW4392345611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.