Evidence map›Paper›PMID 38463975›Full record

ArticlebioRxiv : the preprint server for biology2024

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.

Dipak Panigrahy, Abigail G Kelly, Weicang Wang, Jun Yang, Sung Hee Hwang, Michael Gillespie, Isabella Howard, Carlos Bueno-Beti, Angeliki Asimaki, Vinay Penna and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Dipak PanigrahyDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Abigail G KellyDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Weicang WangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Davis, CA.
Jun YangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Davis, CA.
Sung Hee HwangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Davis, CA.
Michael GillespieDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Isabella HowardDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Carlos Bueno-BetiCardiovascular and Genomics Research Institute, St. George's, University of London, UK.
Angeliki AsimakiCardiovascular and Genomics Research Institute, St. George's, University of London, UK.
Vinay PennaCardiovascular Division, Department of Medicine, Washington University, St. Louis, MO.
Kory LavineCardiovascular Division, Department of Medicine, Washington University, St. Louis, MO.
Matthew L EdinNational Institute of Environmental Health Science.
Darryl C ZeldinNational Institute of Environmental Health Science.
Bruce D HammockDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Davis, CA.
Jeffrey E SaffitzDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Beth Israel Deaconess Medical Center · USUC Davis Comprehensive Cancer CenterOrszagos Kornyezetegeszsegugyi Intezet · HUSt George's, University of London · GBWashington University in St. Louis · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate IntoxicationU54NS127758 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Pamela J Lein · 2022 to 2026
$17.2M
TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
Arrhythmogenic Cardiomyopathy is an Inflammatory DiseaseR01HL148348 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAFFITZ, JEFFREY E · 2020 to 2023
$2.1M
Control of cancer cachexia via stimulation of resolution of inflammationR01CA276107 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Steven David Freedman, Dipak Panigrahy · 2024 to 2026
$2.1M
British Heart Foundation PG/23/11166NCI NIH HHS R01 CA276107NHLBI NIH HHS R01 HL148348NHLBI NIH HHS R35 HL161185NIAID NIH HHS T32 AI007163NIAMS NIH HHS P30 AR073752NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443NINDS NIH HHS U54 NS127758
6 · The paper itself

Abstract

Previous studies have implicated persistent innate immune signaling in the pathogenesis of arrhythmogenic cardiomyopathy (ACM), a familial non-ischemic heart muscle disease characterized by life-threatening arrhythmias and progressive myocardial injury. Here, we provide new evidence implicating inflammatory lipid autocoids in ACM. We show that specialized pro-resolving lipid mediators are reduced in hearts of

Identifiers

PMID38463975
PMCPMC10925075
OpenAlexW4391929465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.