Evidence map›Paper›PMID 38463970›Full record

ArticlebioRxiv : the preprint server for biology2024

Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion.

Tara-Yesomi Wenegieme, Dalia Elased, Kelia E McMichael, Jananie Rockwood, Khanzada Hasrat, Adaku C Ume, Andrea G Marshall, Kit Neikirk, Annet Kirabo, Khalid M Elased and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Tara-Yesomi WenegiemeDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Dalia ElasedDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Kelia E McMichaelDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Jananie RockwoodDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Khanzada HasratDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Adaku C UmeDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN, 37235, USA.
Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN, 37235, USA.
Annet KiraboDepartment of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Khalid M ElasedDepartment of Pharmacology and Toxicology, Wright State University, Dayton, OH 45435 USA.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN, 37235, USA.ORCID 0000-0002-7730-952X
Clintoria R WilliamsDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435 USA.ORCID 0000-0001-7026-7737
Wright State University · USVanderbilt University · US

Funding

Mechanisms of the Renoprotective Properties of Zinc Supplementation in Mouse Models of Chronic Kidney DiseaseR01DK133698 · NIDDK · WRIGHT STATE UNIVERSITY · PI WILLIAMS, CLINTORIA RICHARDS · 2022 to 2025
$1.9M
Role of Calcineurin Isoforms in Renal Regulation of Blood PressureR21DK119879 · NIDDK · WRIGHT STATE UNIVERSITY · PI WILLIAMS, CLINTORIA RICHARDS · 2018 to 2020
$630k
NIDDK NIH HHS R01 DK133698NIDDK NIH HHS R21 DK119879
6 · The paper itself

Abstract

Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases.

Indexed as

Dietary approachMouse ModelZinc DeficiencyZinc Repletion

Identifiers

PMID38463970
PMCPMC10925336
OpenAlexW4392380771

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.