ArticleResearch square2024
Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice.
Tal Frolinger, Funda Korkmaz, Steven Sims, Fazilet Sen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Rani Pallapati, Avi Liu, Satish Rojekar and 15 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
25 authors at 2 institutions in 2 countries.
Tal FrolingerIcahn School of Medicine at Mount Sinai.
Funda KorkmazIcahn School of Medicine at Mount Sinai.
Fazilet SenIcahn School of Medicine at Mount Sinai.
Farhath SultanaIcahn School of Medicine at Mount Sinai.
Victoria LaurencinIcahn School of Medicine at Mount Sinai.
Liam CullenIcahn School of Medicine at Mount Sinai.
Anusha Rani PallapatiIcahn School of Medicine at Mount Sinai.
Avi LiuIcahn School of Medicine at Mount Sinai.
Satish RojekarIcahn School of Medicine at Mount Sinai.
Georgii PevnevIcahn School of Medicine at Mount Sinai.
Uliana CheliadinovaIcahn School of Medicine at Mount Sinai.
Darya VasilyevaIcahn School of Medicine at Mount Sinai.
Guzel BurganovaIcahn School of Medicine at Mount Sinai.
Anne Macdonald
Mansi SaxenaIcahn School of Medicine at Mount Sinai.
Clifford Rosen
Orly BarakIcahn School of Medicine at Mount Sinai.
Daria LiznevaIcahn School of Medicine at Mount Sinai.
Anisa Gumerova
Vitaly RyuIcahn School of Medicine at Mount Sinai.
Tony Yuen
Icahn School of Medicine at Mount Sinai · USShenzhen Institutes of Advanced Technology · CN
Funding
Targeting FSH for the Therapy of Osteoporosis, Obesity and NeurodegenerationU19AG060917 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Mone Zaidi · 2019 to 2026
$29.0MA Humanized Monoclonal FSH Blocking Antibody for Alzheimer's DiseaseU01AG073148 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Tony Yuen, Mone Zaidi · 2021 to 2026
$10.6MElevated FSH - A Driver for Sex Differences in Alzheimer's DiseaseR01AG074092 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, YUEN, TONY · 2021 to 2025
$6.3MProof-of-Concept and Mechanistic Studies to Repurpose Erectile Dysfunction Drugs for Elderly FemalesR01AG071870 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIM, SE-MIN, YUEN, TONY · 2021 to 2025
$3.9MThyrotropin Receptor, Thyrotropin and Mechanisms of Bone LossR01DK113627 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAVIES, TERRY FRANCIS, IQBAL, JAMEEL Z · 2017 to 2020
$2.8MNIA NIH HHS R01 AG071870NIA NIH HHS R01 AG074092NIA NIH HHS U01 AG073148NIA NIH HHS U19 AG060917NIDDK NIH HHS R01 DK113627
6 · The paper itselfAbstract
Alzheimer's disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post-menopausal levels of the pituitary gonadotropin follicle-stimulating hormone (FSH) are strongly associated with the onset of AD, and we have shown recently that FSH directly activates the hippocampal Fshr to drive AD-like pathology and memory loss in mice. To establish a role for FSH in memory loss, we used female
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PMID38463956
PMCPMC10925392
OpenAlexW4392297939
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