ArticlebioRxiv : the preprint server for biology2025
Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in
Marilina Raices, Fabiola Balmir, Nicola Silva, Wei Li, McKenzie K Grundy, Dane K Hoffman, Elisabeth Altendorfer, Carlos Jaime Camacho, Kara A Bernstein, Monica P Colaiácovo and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 6 institutions in 3 countries.
Marilina RaicesMagee-Womens Research Institute, Pittsburgh, PA 15213 USA.
Fabiola BalmirMagee-Womens Research Institute, Pittsburgh, PA 15213 USA.
Wei LiMagee-Womens Research Institute, Pittsburgh, PA 15213 USA.
McKenzie K GrundyDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Dane K HoffmanMagee-Womens Research Institute, Pittsburgh, PA 15213 USA.
Elisabeth AltendorferDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Carlos Jaime CamachoDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213 USA.ORCID 0000-0003-1741-8529 Kara A BernsteinDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Monica P ColaiácovoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.ORCID 0000-0001-7803-4372 Magee-Womens Research Institute · USHarvard University · USUniversity of Pittsburgh · USMasaryk University · CZPenn Center for AIDS Research · USUPMC Hillman Cancer Center · US
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3MSynaptonemal Complex Assembly and Function in MeiosisR01GM072551 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Monica P Colaiacovo · 2005 to 2026
$7.5MReplication fork dynamics and repair by Rad51 paralogues after DNA alkylationR01ES030335 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kara A Bernstein · 2019 to 2026
$2.9MUndergraduate Summer Research Supplement for 5R01GM104007-07: Characterization of a Meiotic Crossover Surveillance SystemR01GM104007 · NIGMS · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI YANOWITZ, JUDITH L · 2013 to 2021
$2.6MLeica STELLARIS Confocal to Power Women's Health ResearchS10OD030404 · OD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI YANOWITZ, JUDITH L · 2021 to 2021
$497kNIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES030335NIGMS NIH HHS R01 GM072551NIGMS NIH HHS R01 GM104007NIH HHS S10 OD030404
6 · The paper itselfAbstract
Double-strand breaks (DSBs) are the most deleterious lesions experienced by our genome. Yet, DSBs are intentionally induced during gamete formation to promote the exchange of genetic material between homologous chromosomes. While the conserved topoisomerase-like enzyme Spo11 catalyzes DSBs, additional regulatory proteins-referred to as "Spo11 accessory factors"- regulate the number, timing, and placement of DSBs during meiotic prophase ensuring that SPO11 does not wreak havoc on the genome. Despite the importance of the accessory factors, they are poorly conserved at the sequence level suggesting that these factors may adopt unique functions in different species. In this work, we present a detailed analysis of the genetic and physical interactions between the DSB factors in the nematode
Indexed as
C. elegansCrossoverdouble-strand breakmeiosisSPO11
Identifiers
PMID38463951
PMCPMC10925144
OpenAlexW4392244042
What OpenQuestion holds
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LicenceCC BY
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