Evidence map›Paper›PMID 38463710›Full record

ArticleFrontiers in molecular biosciences2024

Diosgenin alleviates D-galactose-induced oxidative stress in rats' brain and liver targeting aging and apoptotic marker genes.

Ali H El-Far, Mona M Elghaity, Shymaa A Mohamed, Ahmed E Noreldin, Yaser H A Elewa, Soad Khalil Al Jaouni, Abdelwahab A Alsenosy

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In one paragraph

Article in Frontiers in molecular biosciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali H El-Far *Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Mona M Elghaity *Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Shymaa A MohamedMolecular Biology Unit, Medical Technology Centre, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Ahmed E NoreldinHistology and Cytology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Yaser H A ElewaDepartment of Histology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Soad Khalil Al JaouniDepartment of Hematology/Pediatric Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdelwahab A AlsenosyDepartment of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants. To alleviate the oxidative stress, we investigated the protective effect of diosgenin (DSG) for D-galactose (D-gal) using 20 and 40 mg of DSG/kg/day/orally for 42 days. The findings showed that D-gal caused brain and liver oxidative injuries by upregulating aging and oxidative markers. To counteract the oxidative stress caused by D-gal, DSG upregulated glutathione peroxidase-1, superoxide dismutase-1, and glutathione S-transferase-α. DSG also diminished the expression of

Indexed as

agingantioxidantsbraindiosgeninliveroxidative stress

Identifiers

PMID38463710
PMCPMC10922004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.