Evidence map›Paper›PMID 38463639›Full record

ArticleBiochemistry and biophysics reports2024

Role of plant homeodomain finger protein 8 in P19 embryonic carcinoma cells revealed by genome editing and specific inhibitor.

Shusuke Doi, Takayoshi Suzuki, Shuhei Soeda, Naoki Miyata, Tetsuya Inazu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shusuke DoiGraduate School of Pharmacy, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan.
Takayoshi SuzukiSANKEN, Osaka University, Ibaraki, Osaka, 567-0047, Japan.
Shuhei SoedaDepartment of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan.
Naoki MiyataInstitute of Dug Discovery Science, Nagoya City University, Mizuho, Nagoya, 467-8603, Japan.
Tetsuya InazuGraduate School of Pharmacy, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation and certain types of cancers, the role of PHF8 remains largely unknown, and its relevance to the pathogenesis of these diseases is also uncertain. In the present study, we aimed to clarify the cellular function of PHF8 in P19 cells using

Indexed as

Cell proliferationCRISPR-Cas9 systemMitogen-activated protein kinase–extracellular signal-regulated kinaseNeuronal differentiationPHF8-specific inhibitorplant homeodomain finger protein 8

Identifiers

PMID38463639
PMCPMC10923654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.