Evidence map›Paper›PMID 38463545›Full record

ArticleJournal of hepatocellular carcinoma2024

Efficacy and Safety of Conversion Surgery for Advanced Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy.

Wenxuan Li, Zhikai Zheng, Jiongliang Wang, Tianqing Wu, Juncheng Wang, Yangxun Pan, Jinbin Chen, Dandan Hu, Li Xu, Yaojun Zhang and 2 more

Abstract read
In one paragraph

Article in Journal of hepatocellular carcinoma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenxuan Li *Cancer Center, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, Guangdong, People's Republic of China.
Zhikai Zheng *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0000-0003-4587-2665
Jiongliang Wang *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Tianqing Wu *Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0009-0009-9733-0260
Juncheng WangDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Yangxun PanDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0000-0002-3887-5852
Jinbin ChenDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0000-0002-6619-1247
Dandan HuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Li XuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0000-0003-4405-1048
Yaojun ZhangDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.ORCID 0000-0002-9752-4729
Minshan ChenDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Zhongguo ZhouDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The aim of this study was to investigate the efficacy and safety of conversion surgery for advanced hepatocellular carcinoma (HCC) after hepatic arterial infusion chemotherapy (HAIC). Patients and Methods: Data from 172 HCC patients treated at Sun Yat-sen University Cancer Center between January 2016 and June 2021 with effective assessment of HAIC treatment response were retrospectively analyzed. Clinical pathological data, treatment process, survival, and occurrence of adverse events were recorded. Patients were grouped according to whether they achieved imaging remission after HAIC, underwent conversion surgery, and met the surgical resection criteria. Efficacy and safety were analyzed. Results: The median progression-free survival (PFS) and overall survival (OS) in the imaging remission group were 8.6 months and 26.3 months, respectively, which were longer than the 4.6 months ( Conclusion: HAIC-based conversion therapy had acceptable toxic effects and could effectively stabilize intrahepatic lesions in advanced HCC, improve the survival benefit of patients, and provide some patients with the opportunity for conversion surgery to further improve prognosis.

Indexed as

advanced hepatocellular carcinomaconversion therapyhepatic arterial infusion chemotherapy

Identifiers

PMID38463545
PMCPMC10922940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.