Evidence map›Paper›PMID 38463525›Full record

ArticleOpen medicine (Warsaw, Poland)2024

METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients.

Quandan Tan, Le Yang, Shanshan Yuan, Danni Zheng, Yapeng Lin, Kejie Chen, Ying He, Shuntian Chen, Junli Hao, Jin Dai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recent research progress on the mechanisms of clopidogrel resistance.European journal of clinical pharmacology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Quandan TanDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Le YangDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Shanshan YuanDepartment of Critical Care Medicine, The General Hospital of Western Theater Command, Chengdu, China.
Danni ZhengBiomedical Informatics and Digital Health, School of Medical Sciences, University of Sydney, Sydney, Australia.
Yapeng LinDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Kejie ChenSchool of Public Health, Chengdu Medical College, Chengdu, China.
Ying HeDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Shuntian ChenSchool of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu, China.
Junli HaoSchool of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu, China.
Jin DaiSchool of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu, China.
Song HeDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Fengkai MaoDepartment of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Xinyi LengDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Haisong JiangDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jie YangDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: N6-methyladenosine (m Methods: We analyzed the m Results: Methyltransferase-like 3 (METTL3), an m Conclusion: The METTL3-mediated methylation of CYP2C19 mRNA may aggravate CR in IS patients.

Indexed as

clopidogrel resistanceCYP2C19ischemic strokeMETTL3N6-methyladenosine

Identifiers

PMID38463525
PMCPMC10921439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.