Evidence map›Paper›PMID 38463444›Full record

ArticleHemaSphere2024

André Almeida, Sara T'Sas, Luca Pagliaro, Igor Fijalkowski, Wouter Sleeckx, Hannah Van Steenberge, Raffaella Zamponi, Béatrice Lintermans, Wouter Van Loocke, Bruno Palhais and 16 more

Abstract read
In one paragraph

Article in HemaSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

André AlmeidaNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Sara T'SasNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Luca PagliaroNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Igor FijalkowskiCancer Research Institute Ghent (CRIG) Ghent Belgium.
Wouter SleeckxCancer Research Institute Ghent (CRIG) Ghent Belgium.
Hannah Van SteenbergeCancer Research Institute Ghent (CRIG) Ghent Belgium.
Raffaella ZamponiDepartment of Medicine and Surgery University of Parma Parma Italy.
Béatrice LintermansNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Wouter Van LoockeNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Bruno PalhaisNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Alexandra ReekmansNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Valentina BardelliInstitute of Hematology and Center for Hemato-Oncology Research University of Perugia and S.M. Misericordia Hospital Perugia Italy.
Lisa DemoenNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.ORCID 0000-0001-7035-0266
Lindy ReunesNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Dieter DeforceLaboratory of Pharmaceutical Biotechnology Ghent University Ghent Belgium.
Filip Van NieuwerburghLaboratory of Pharmaceutical Biotechnology Ghent University Ghent Belgium.
Alex KentsisTow Center for Developmental Oncology, Sloan Kettering Institute and Department of Pediatrics Memorial Sloan Kettering Cancer Center New York New York USA.
Panagiotis NtziachristosCancer Research Institute Ghent (CRIG) Ghent Belgium.
Nadine Van RoyCancer Research Institute Ghent (CRIG) Ghent Belgium.
Barbara De MoerlooseCancer Research Institute Ghent (CRIG) Ghent Belgium.
Cristina MecucciInstitute of Hematology and Center for Hemato-Oncology Research University of Perugia and S.M. Misericordia Hospital Perugia Italy.
Roberta La StarzaInstitute of Hematology and Center for Hemato-Oncology Research University of Perugia and S.M. Misericordia Hospital Perugia Italy.
Giovanni RotiDepartment of Medicine and Surgery University of Parma Parma Italy.
Steven GoossensCancer Research Institute Ghent (CRIG) Ghent Belgium.
Pieter Van VlierbergheNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.
Tim PietersNormal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine Ghent University Ghent Belgium.ORCID https://orcid.org/0000-0002-2958-0104

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that accounts for 10%-15% of pediatric and 25% of adult ALL cases. Although the prognosis of T-ALL has improved over time, the outcome of T-ALL patients with primary resistant or relapsed leukemia remains poor. Therefore, further progress in the treatment of T-ALL requires a better understanding of its biology and the development of more effective precision oncologic therapies. The proto-oncogene

Identifiers

PMID38463444
PMCPMC10924755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.