Evidence map›Paper›PMID 38463363›Full record

ArticleWorld journal of gastrointestinal surgery2024

Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging.

Zhi-Ren Chen, Mei-Fang Yang, Zhi-Yuan Xie, Pei-An Wang, Liang Zhang, Ze-Hua Huang, Yao Luo

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Article in World journal of gastrointestinal surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhi-Ren ChenDepartment of Science and Education, Xuzhou Medical University, Xuzhou Clinical College, Xuzhou 221000, Jiangsu Province, China.
Mei-Fang YangDepartment of Neurology, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Zhi-Yuan XieDepartment of Neurology, Clinical Laboratory, Gastrointestinal Surgery, Central Hospital of Xuzhou, Central Hospital of Xuzhou, Xuzhou 221000, Jiangsu Province, China.
Pei-An WangDepartment of Public Health, Xuzhou Central Hospital, Xuzhou 221000, Jiangsu Province, China. 302303121267@stu.xzhmu.edu.cn.
Liang ZhangDepartment of Gastroenterology, Xuzhou Centre Hospital, Xuzhou 221000, Jiangsu Province, China.
Ze-Hua HuangDepartment of Public Health, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Yao LuoDepartment of Public Health, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) is prevalent and aggressive, especially when patients have distant lung metastases, which often places patients into advanced stages. By identifying prognostic variables for lung metastasis in GC patients, it may be possible to construct a good prediction model for both overall survival (OS) and the cumulative incidence prediction (CIP) plot of the tumour.

aimTo investigate the predictors of GC with lung metastasis (GCLM) to produce nomograms for OS and generate CIP by using cancer-specific survival (CSS) data.

methodsData from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance, epidemiology, and end results program database. The major observational endpoint was OS; hence, patients were separated into training and validation groups. Correlation analysis determined various connections. Univariate and multivariate Cox analyses validated the independent predictive factors. Nomogram distinction and calibration were performed with the time-dependent area under the curve (AUC) and calibration curves. To evaluate the accuracy and clinical usefulness of the nomograms, decision curve analysis (DCA) was performed. The clinical utility of the novel prognostic model was compared to that of the 7

resultsFor the purpose of creating the OS nomogram, a CIP plot based on CSS was generated. Cox multivariate regression analysis identified eleven significant prognostic factors (

conclusionThe OS nomogram for GCLM successfully predicts 1- and 3-year OS. Moreover, this approach can help to appropriately classify patients into high-risk and low-risk groups, thereby guiding treatment.

Indexed as

EpidemiologyGastric cancerLung metastasisNomogramsOverall survivalPrognosisSurveillanceSurveillance epidemiology and end results program database

Identifiers

PMID38463363
PMCPMC10921188

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