Evidence map›Paper›PMID 38463246›Full record

ArticleACS omega2024

Nonenzymatic Potentiometric Detection of Ascorbic Acid with Porphyrin/ZnO-Functionalized Laser-Induced Graphene as an Electrode of EGFET Sensors.

Kishore Pushparaj, Alexandro Catini, Rosamaria Capuano, Valerio Allegra, Gabriele Magna, Gianni Antonelli, Eugenio Martinelli, Antonio Agresti, Sara Pescetelli, Yuvaraj Sivalingam and 2 more

Abstract read
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In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kishore PushparajDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-6170-7291
Alexandro CatiniDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.
Rosamaria CapuanoDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.
Valerio AllegraDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.
Gabriele MagnaDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0003-2140-0110
Gianni AntonelliDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-4658-4000
Eugenio MartinelliDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.
Antonio AgrestiDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0001-6581-0387
Sara PescetelliDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-3336-2425
Yuvaraj SivalingamDepartment of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India.ORCID https://orcid.org/0000-0002-2079-1570
Roberto PaolesseDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-2380-1404
Corrado Di NataleDepartment of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-0543-4348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laser-induced graphene (LIG) has emerged as a highly versatile material with significant potential in the development of electrochemical sensors. In this paper, we investigate the use of LIG and LIG functionalized with ZnO and porphyrins-ZnO as the gate electrodes of the extended gate field effect transistors (EGFETs). The resultant sensors exhibit remarkable sensitivity and selectivity, particularly toward ascorbic acid. The intrinsic sensitivity of LIG undergoes a notable enhancement through the incorporation of hybrid organic-inorganic materials. Among the variations tested, the LIG electrode coated with zinc tetraphenylporphyrin-capped ZnO nanoparticles demonstrates superior performance, reaching a limit of detection of approximately 3 nM. Furthermore, the signal ratio for 5 μM ascorbic acid relative to the same concentration of dopamine exceeds 250. The practical applicability of these sensors is demonstrated through the detection of ascorbic acid in real-world samples, specifically in a commercially available food supplement containing l-arginine. Notably, formulations with added vitamin C exhibit signals at least 25 times larger than those without, underscoring the sensors' capability to discern and quantify the presence of ascorbic acid in complex matrices. This research not only highlights the enhanced performance of LIG-based sensors through functionalization but also underscores their potential for practical applications in the analysis of vitamin-rich supplements.

Identifiers

PMID38463246
PMCPMC10918774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.