ArticleBMC public health2024
The interaction between general or abdominal obesity and hypertension on the risk of type 2 diabetes mellitus: a cross-sectional analysis in Iranian adults from the RaNCD cohort study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 10 citations in OpenAlex.
- Functional limitation and cardiometabolic health: a cross-sectional exploration in adults aged 30 and older in rural Punjab, India.BMC public health · 2026Article
- Cardiorenal protective effects of dapagliflozin combined with valsartan in patients with type 2 diabetes mellitus and hypertension: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- The association between body roundness index and osteoporosis in older patients: a cross-sectional study based on a comprehensive geriatric assessment.BMC geriatrics · 2025Article
- Patterns of type 2 diabetes risk factors using latent class analysis (LCA) model: a population-based study in the South of Iran, Kharameh cohort population.BMC public health · 2025Article
- Socioeconomic disparities in multimorbidity of chronic diseases in the RaNCD cohort study.Scientific reports · 2025Article
- Integrating causal human genetics andFrontiers in molecular biosciences · 2025Article
- Blood Pressure Control and Anthropometric Differences in Afro-Descendants and Other Ethnic Groups in Hypertensive Brazilian Populations.Global heart · 2025Article
- Dose-response relationship between body mass index and hypertension: A cross-sectional study from Eastern China.Preventive medicine reports · 2024Article
- Association of body roundness index with female infertility: 2013-2018 NHANES.Frontiers in nutrition · 2024Article
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8 authors at 1 institution in 1 country.
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Abstract
backgroundInteractions between risk factors may influence disease severity. Knowing this relationship is important for preventive interventions and disease control. The purpose of this study was to determine the interactions effects of obesity and hypertension on the risk of type 2 diabetes mellitus (T2DM).
methodsThe data of 9,283 adults 35 to 65 years were examined from the cohort study of Ravansar Non-Communicable Disease (RaNCD). Waist circumference (WC) was used to identify both general and abdominal obesity based on body mass index (BMI). To assess the interaction between hypertension and obesity (general/abdominal) and the risk of T2DM, the additive interaction was calculated.
resultsThe adjusted odds ratios for T2DM were 2.38 (1.67, 3.41) in men and 4.02 (2.47, 6.47) in women for the combinations of hypertension and abdominal obesity. The adjusted odds ratios for T2DM were 2.53 (1.63, 3.82) in men and 2.66 (1.92, 3.70) in women for the combinations of hypertension and general obesity. The results of the additive interaction indicators were inconsistent with gender. The relative excess risk due to interaction (interaction between hypertension and central obesity) (RERI), attributable proportion due to interaction (AP) and synergy index (SI) were0.27 (-1.01, 1.54), 0.11 (-0.41, 0.63) and 1.23 (0.41, 3.68) in male and were 0.61 (-1.12, 2.33), 0.23 (0.08, 0.37) and 1.26 (0.60, 2.61) in female, respectively.
conclusionGeneral/abdominal obesity and hypertension have a synergistic effect on the risk of T2DM. The recommendation for preventing T2DM is lifestyle modification. Large longitudinal studies are necessary to investigate causal relationships.
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