Evidence map›Paper›PMID 38462569›Full record

ArticleGeroScience2024

Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance.

Lihong Pan, Xiaochen He, Rui Xu, Umesh Bhattarai, Ziru Niu, Jussara do Carmo, Yuxiang Sun, Heng Zeng, John S Clemmer, Jian-Xiong Chen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lihong Pan *Department of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Xiaochen He *Department of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Rui XuDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Umesh BhattaraiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Ziru NiuDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Jussara do CarmoDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Yuxiang SunDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Heng ZengDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
John S ClemmerDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA.
Jian-Xiong ChenDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Yingjie ChenDepartment of Physiology and Biophysics, University of Mississippi Medical Center, School of Medicine, 2500 North State Street, Jackson, MS, 39216, USA. ychen2@umc.edu.ORCID 0000-0002-4059-7847
State Street (United States) · USUniversity of Mississippi Medical Center · USTexas A&M University · US

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVID E STEC · 2023 to 2026
$6.3M
Mechanism of  PD1 on cardiac inflammation resolution during heart failure developmentR01HL161085 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2022 to 2025
$2.3M
Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart HypertrophyR01HL139797 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2018 to 2021
$2.2M
Endothelial PHD2 in hypertensive vascular remodelingR01HL151536 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, JIAN-XIONG · 2021 to 2024
$1.6M
American Heart Association 23POST1029902American Heart Association-American Stroke AssociationNational Institute of Health R01HL139797National Institute of Health R01HL161085National institute of health (US) R01HL151536NHLBI NIH HHS P01 HL051971NHLBI NIH HHS R01 HL139797NHLBI NIH HHS R01 HL151536NHLBI NIH HHS R01 HL161085NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404
6 · The paper itself

Abstract

Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF) protein. Using vascular endothelial cell-specific PHD2 gene knockout (PHD2 ECKO) mice, we investigated the role of endothelial PHD2 in aging-related obesity and exercise capacity. Briefly, PHD2 ECKO mice were obtained by crossing PHD2-floxed mice with VE-Cadherin (Cdh5)-Cre transgenic mice. The effect of PHD2 ECKO on obesity and exercise capacity in PHD2 ECKO mice and control PHD2

Indexed as

AgingExercise ToleranceHypoxia-Inducible Factor-Proline DioxygenasesMice, KnockoutObesityAnimalsDisease Models, AnimalInsulin ResistanceMaleMiceOxygen ConsumptionPhysical Conditioning, AnimalEgln1 protein, mouseHypoxia-Inducible Factor-Proline DioxygenasesAgingEnergy expenditureInsulin resistanceMetabolismObesity

Identifiers

PMID38462569
PMCPMC11226575
OpenAlexW4392654032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.