Evidence map›Paper›PMID 38462515›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Tyrosine Kinase Inhibitor-induced Cerebrovascular Occlusion Presenting with Moyamoya Disease-like Stenosis of the Circle of Willis.

Takuya Terakawa, Yuya Hayasaka, Yuka Umeki, Mako Ikeda, Yoshiki Matsuoka, Masanari Mizuki, Shogo Matsui, Wataru Nakahara, Hitomi Matsunaga, Shayne Morris and 4 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takuya TerakawaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Yuya HayasakaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Yuka UmekiDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Mako IkedaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Yoshiki MatsuokaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Masanari MizukiDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Shogo MatsuiDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Wataru NakaharaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Hitomi MatsunagaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
Shayne MorrisDepartment of Neurosurgery, Hyogo Prefectural Nishinomiya Hospital, Japan.
Takeo NishidaDepartment of Neurosurgery, Hyogo Prefectural Nishinomiya Hospital, Japan.
Takayuki SakakiDepartment of Neurosurgery, Japan Community Health Care Organization Osaka Hospital, Japan.
Takeshi YoshimotoDepartment of Neurology, National Cerebral and Cardiovascular Center, Japan.
Shuji UedaDepartment of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular occlusive events are notable adverse effects of tyrosine kinase inhibitors (TKIs), which are promising treatments for chronic myeloid leukemia (CML). We herein report the case of a patient with CML who developed cerebrovascular occlusion of the circle of Willis during TKI treatment. Our patient did not meet the diagnostic criteria for moyamoya disease due to the insignificant development of moyamoya vessels. The lack of moyamoya vessel development may be explained by the suppression of tyrosine kinases that are responsible for angiogenesis. Cerebrovascular occlusion of the circle of Willis, without significant development of moyamoya vessels, may be an important phenotype of TKI-associated vasculopathy.

Indexed as

Circle of WillisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMoyamoya DiseaseProtein Kinase InhibitorsCerebrovascular DisordersConstriction, PathologicFemaleHumansMaleMiddle AgedTyrosine Kinase InhibitorsProtein Kinase InhibitorsTyrosine Kinase Inhibitorscerebrovascular occlusion of the circle of Willischronic myeloid leukemiamoyamoya diseasemoyamoya vesselstyrosine kinase inhibitor

Identifiers

PMID38462515
PMCPMC11604399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.