Evidence map›Paper›PMID 38462410›Full record

ArticleAmerican journal of surgery2024

The overtreatment of papillary thyroid microcarcinoma in the community.

Peter J Abraham, Christopher Wu, Rongzhi Wang, Brendon Herring, Polina Zmijewski, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Herbert Chen

Abstract read
In one paragraph

Article in American journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Decision-making value of a 1-cm tumor diameter cut-off for postoperativeAmerican journal of translational research · 2026
    Article
  5. Article
  6. Article
  7. Beyond the Neck: When Is Thoracic Operation Needed for Thyroidectomy?Journal of the American College of Surgeons · 2025
    Article
  8. Loss of Follow-up for Thyroid Nodules in Patients Living in Poverty.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Redo Thyroidectomy: Updated Insights.Journal of clinical medicine · 2024
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter J AbrahamUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Christopher WuUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Rongzhi WangUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Brendon HerringUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Polina ZmijewskiUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Andrea GillisUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Jessica FazendinUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Brenessa LindemanUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA.
Herbert ChenUniversity of Alabama at Birmingham, Department of General Surgery, Birmingham, AL, USA. Electronic address: hchen@uabmc.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Characterizing the Role of NOTCH2 in Neuroendocrine TumorsF31CA260945 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERRING, BRENDON ROBERT · 2022 to 2024
$125k
NCI NIH HHS F31 CA260945NIGMS NIH HHS T32 GM008361
6 · The paper itself

Abstract

introductionTotal thyroidectomy is the traditional primary approach for papillary thyroid cancer. However, recent evidence supports conservative management for low-risk tumors like papillary thyroid microcarcinomas (PTMCs). This study explores the adoption of these practices in our community, using a cancer database to analyze treatment strategies.

methodsA retrospective review of a 1433-patient institutional database identified 258 ​PTMC cases. Outcomes, including 30-day mortality, reoperation rate, postoperative hypocalcemia, and recurrent laryngeal nerve (RLN) injury, were assessed.

resultsOf PTMC patients, 63.4% underwent total thyroidectomy, with higher rates of RLN injury (8.8% vs. 2.3%) and hypocalcemia (12.4% vs. 0.0%) compared to lobectomy. Non-endocrine surgeons had higher postoperative radioactive iodine administration rates (28.6% vs. 6.1%). Subgroup analysis revealed a shift in total thyroidectomy rates based on tumor size and surgery period.

conclusionOur community favors total thyroidectomy for PTMC, despite associated complications. Enhanced awareness and adherence to PTMC best practice guidelines are warranted.

Indexed as

Carcinoma, PapillaryOvertreatmentThyroidectomyThyroid NeoplasmsAdultAgedFemaleHumansHypocalcemiaMaleMiddle AgedPostoperative ComplicationsRecurrent Laryngeal Nerve InjuriesReoperationRetrospective StudiesLobectomyPapillary thyroid microcarcinomaThyroid cancerTotal thyroidectomy

Identifiers

PMID38462410
PMCPMC11325562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.