Observational studySurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2024
Sex- and operation-dependent effects on 5-year weight loss results of bariatric surgery.
Observational study in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Influence of Biological Sex on Metabolic and Adipokine Responses after Metabolic-Bariatric Surgery: A Narrative Review.Current obesity reports · 2026Review
- Online Media Platform and Continuous Positive Airway Pressure Machine Purchasing Prior to Bariatric Surgery: Qualitative Study.Asian/Pacific Island nursing journal · 2026Article
- Bariatric Surgery without Regret: A Prospective Analysis of Patient Satisfaction, Weight Loss, and Quality of Life Outcomes.Obesity surgery · 2026Article
- Laparoscopic Roux-en-Y Gastric Bypass: Evolution of Weight Loss and Metabolic Obesity-Related Complications After 15-20 Years.Obesity surgery · 2025Article
- Total Alimentary Limb Length Is Not Associated with Weight Loss Following Proximal Roux-en-Y Gastric Bypass.Obesity surgery · 2025Observational
- Reduced Risk of Cardiovascular Diseases After Bariatric Surgery Based on the New Predicting Risk of Cardiovascular Disease EVENTs Equations.Journal of the American Heart Association · 2025Article
- Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Determinants of Weight Loss and Regain in Men After Roux-En-Y Gastric Bypass: A Retrospective Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Body Composition Changes and Factors Influencing the Total Weight Loss Rate After Laparoscopic Sleeve Gastrectomy.Clinics and practice · 2024Article
- Bariatric Surgery Is Associated with Lower Concentrations of Fecal Secondary Bile Acids and Their Metabolizing Microbial Enzymes: A Pilot Study.Obesity surgery · 2024Article
- Adverse event comparison between glucagon-like peptide-1 receptor agonists and other antiobesity medications following bariatric surgery.Diabetes, obesity & metabolism · 2024Article
- Reduced Risk of Cardiovascular Diseases after Bariatric Surgery Based on the New PREVENT Equations.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundWeight loss response after bariatric surgery is highly variable, and several demographic factors are associated with differential responses to surgery. Preclinical studies demonstrate numerous sex-specific responses to bariatric surgery, but whether these responses are also operation dependent is unknown.
objectiveTo examine sex-specific weight loss outcomes up to 5 years after laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).
settingSingle center, university, United States.
methodsRetrospective, observational cohort study including RYGB (n = 5057) and vertical SG (n = 2041) patients from a single, academic health center. Percentage total weight loss (TWL) over time was examined with generalized linear mixed models to determine the main and interaction effects of surgery type on weight loss by sex.
resultsTWL demonstrated a strong sex-by-procedure interaction, with women having a significant advantage with RYGB compared with SG (adjusted difference at 5 yr: 8.0% [95% CI: 7.5-8.5]; P < .001). Men also experienced greater TWL over time with RYGB or SG, but the difference was less and clinically insignificant (adjusted difference at 5 yr: 2.9% [2.0-3.8]; P < .001; P interaction between sex and procedure type = .0001). Overall, women had greater TWL than men, and RYGB patients had greater TWL than SG patients (adjusted difference at 5 yr: 3.1% [2.4-3.2] and 6.9% [6.5-7.3], respectively; both P < .0001). Patients with diabetes lost less weight compared with those without (adjusted difference at 5 yr: 3.0% [2.7-3.2]; P < .0001).
conclusionsWeight loss after bariatric surgery is sex- and procedure-dependent. There is an association suggesting a clinically insignificant difference in weight loss between RYGB and SG among male patients at both the 2- and 5-year postsurgery time points.
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