SynthesisGerontology2024
Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.
Synthesis in Gerontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Linking dementia prodromes and cancer through motor function impairment: the Rotterdam-Study.BMC geriatrics · 2026Article
- Association between depressive symptom trajectories and motoric cognitive risk syndrome in older adults: a cohort study.BMC geriatrics · 2026Article
- Review
- Association of weight-adjusted waist index with motoric cognitive risk syndrome in Chinese adults Aged ≥ 60 years.Lipids in health and disease · 2025Article
- Physical fitness and incident mild cognitive impairment: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Review
- Cross-domain latent profiles of MCI and dementia are most differentiated by social and emotional functioning.Journal of the International Neuropsychological Society : JINS · 2025Article
- Association of motoric cognitive risk syndrome with falls in older adults: findings from three longitudinal studies.BMC geriatrics · 2025Article
- Association between Motoric Cognitive Risk Syndrome and Indicators of Reflecting Independent Living among Community-Dwelling Older Adults in Japan: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiologic studies have indicated an association of motoric cognitive risk syndrome (MCR), a pre-dementia stage characterized by the presence of cognitive complaints and a slow gait, with increased risk of incident dementia.
objectivesWe aimed to clarify this association using meta-analysis.
methodsWe systematically searched the PubMed, Embase, and Web of Science databases up to December 2022 for relevant studies that investigated the association between MCR and incident all-cause dementia and Alzheimer's disease (AD). The random-effects model was used to determine a pooled-effect estimate of the association.
resultsWe identified seven articles that corresponded with nine cohort studies investigating the association between MCR and the risk of dementia. Pooled analysis showed that MCR was associated with a significantly increased risk of incident all-cause dementia (HR = 2.28; 95% CI: 1.90-2.73) and AD (HR = 2.05; 95% CI: 1.61-2.61). Sensitivity analysis showed that there was no evidence that individual studies influenced the pooled-effect estimate, verifying the robustness of the results.
conclusionsOur results confirm that MCR is an independent risk factor of incident all-cause dementia and AD. Future studies are needed to better understand the mechanisms underlying this association.
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