Evidence map›Paper›PMID 38461443›Full record

SynthesisActa diabetologica2024

Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome.

Marco Meloni, Laura Giurato, Luca Monge, Cesare Miranda, Alessia Scatena, Benedetta Ragghianti, Giovanni Antonio Silverii, Cristiana Vermigli, Alessandro De Cassai, Antonio Volpe and 22 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Acta diabetologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  6. [Minimally invasive surgery for Charcot arthropathy].Orthopadie (Heidelberg, Germany) · 2026
    Review
  7. Observational
  8. Semaglutide - properties, action and chromatographic analysis.Journal of diabetes and metabolic disorders · 2025
    Review
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  12. Observational
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 1 country.

Marco MeloniDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. meloni.marco@libero.it.ORCID http://orcid.org/0000-0003-3789-9622
Laura GiuratoDepartment of Endocrinology and Diabetology, CTO Hospital, 00145, Rome, Italy.
Luca MongeAMD-Italian Association of Clinical Diabetologists, Milan, Italy.
Cesare MirandaPordenone Hospital, Pordenone, Italy.
Alessia ScatenaOspedale San Donato, Arezzo, Italy.
Benedetta RagghiantiAzienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, 50141, Florence, Italy.
Giovanni Antonio SilveriiAzienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, 50141, Florence, Italy.
Cristiana VermigliAzienda Ospedaliera Santa Maria Della Misericordia, Ospedale Di Perugia, Perugia, Italy.
Alessandro De CassaiUniversity Hospital of Padua, Padua, Italy.
Antonio VolpePoliclinico Abano Terme, Padua, Italy.
Rodolfo TramontaAsl Roma 4, Civitavecchia, Italy.
Gerardo MedeaSIMG- Italian Society of General Medicine, Florence, Italy.
Corrado BordieriUniversità Cattolica del Sacro Cuore, Rome, Italy.
Marco FalconeCisanello Hospital and University of Pisa, Pisa, Italy.
Laura StefanonAzienda Sanitaria Friuli Occidentale, Pordenone, Italy.
Andrea BernettiSapienza University, Rome, Italy.
Cristina CappellaAssociazione Di Volontariato Piede Diabetico Umbria ODV, Perugia, Italy.
Mauro GargiuloUniversity of Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy.
Valentina LorenzoniScuola Superiore Sant'Anna, Pisa, Italy.
Germano ScevolaOspedale Sandro Pertini, Rome, Italy.
Eugenio StabileAzienda Ospedaliera Regionale "San Carlo", Potenza, Italy.
Roberto Da RosAzienda Sanitaria Universitaria Giuliana Isontina, Monfalcone, Italy.
Giuseppe MurdoloAzienda Ospedaliera Santa Maria Della Misericordia, Ospedale Di Perugia, Perugia, Italy.
Eleonora BianchiniAzienda Ospedaliera Santa Maria Della Misericordia, Ospedale Di Perugia, Perugia, Italy.
Francesco GaggiaAzienda Ospedaliera Santa Maria Della Misericordia, Ospedale Di Perugia, Perugia, Italy.
Carlotta GaunaASL Città Di Torino, Turin, Italy.
Francesco RomeoASL TO5, Chieri, Turin, Italy.
Matteo ApicellaOspedale San Donato, Arezzo, Italy.
Michele MantuanoOspedale San Donato, Arezzo, Italy.
Matteo MonamiAzienda Ospedaliero Universitaria Careggi, Largo Brambilla 3, 50141, Florence, Italy.
Luigi UccioliDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Panel of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome and on behalf of SID and AMD
Azienda Ospedaliera di Perugia · ITAzienda Ospedaliero-Universitaria Careggi · ITOspedale San Donato · ITUniversity of Rome Tor Vergata · ITAssociazione Medici Diabetologi · ITAzienda Ospedaliera Carlo Poma · ITAzienda Sanitaria Universitaria Integrata di Trieste · ITAzienda Unità Sanitaria Locale di Ferrara · ITCTO Hospital · ITFondazione Cassa di Risparmio Civitavecchia · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITOspedale di Spoleto · ITOspedale Sandro Pertini · ITPoliclinico Abano Terme · ITSapienza University of Rome · ITScuola Superiore Sant'Anna · ITSocietà Italiana di Medicina Generale · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Padua · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is useful to achieve good clinical outcomes, reducing major and minor amputation and increasing the chance of healing. Despite this, the multidisciplinary approach is not always a recognized treatment strategy. The aim of this meta-analysis was to assess the effects of an MDT approach on major adverse limb events, healing, time-to-heal, all-cause mortality, and other clinical outcomes in patients with active DFUs. The present meta-analysis was performed for the purpose of developing Italian guidelines for the treatment of diabetic foot with the support of the Italian Society of Diabetology (Società Italiana di Diabetologia, SID) and the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD). The study was performed using the Grading of Recommendations Assessment, Development, and Evaluation approach. All randomized clinical trials and observational studies, with a duration of at least 26 weeks, which compared the MDT approach with any other organizational strategy in the management of patients with DFUs were considered. Animal studies were excluded. A search of Medline and Embase databases was performed up until the May 1st, 2023. Patients managed by an MDT were reported to have better outcomes in terms of healing, minor and major amputation, and survival in comparison with those managed using other approaches. No data were found on quality of life, returning-to-walking, and emergency admission. Authors concluded that the MDT may be effective in improving outcomes in patients with DFUs.

Indexed as

Amputation, SurgicalDiabetic FootPatient Care TeamHumansItalyPractice Guidelines as TopicTreatment OutcomeWound HealingDiabetesDiabetic footLimb salvageMultidisciplinary team

Identifiers

PMID38461443
OpenAlexW4392633379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.