Evidence map›Paper›PMID 38461343›Full record

ArticleNature communications2024

Temporally organized representations of reward and risk in the human brain.

Vincent Man, Jeffrey Cockburn, Oliver Flouty, Phillip E Gander, Masahiro Sawada, Christopher K Kovach, Hiroto Kawasaki, Hiroyuki Oya, Matthew A Howard Iii, John P O'Doherty

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The Anterior Insula Processes a Time-Resolved Subjective Risk Prediction Error.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Vincent ManDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA. vman@caltech.edu.ORCID 0000-0001-5380-5521
Jeffrey CockburnDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0003-2004-8653
Oliver FloutyDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, 33606, USA.
Phillip E GanderDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.ORCID 0000-0003-3945-8820
Masahiro SawadaDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Christopher K KovachDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.ORCID 0000-0002-0117-151X
Hiroto KawasakiDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Hiroyuki OyaDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.ORCID 0000-0002-1733-5478
Matthew A Howard IiiDepartment of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
John P O'DohertyDivision of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, 91125, USA.ORCID 0000-0003-0016-3531
California Institute of Technology · USUniversity of Iowa · USUniversity of Iowa Hospitals and Clinics · USUniversity of South Florida · US

Funding

Neuronal Substrates of Hemodynamic Signals in the Prefrontal CortexR01MH111425 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HOWARD, MATTHEW A., O'DOHERTY, JOHN P · 2016 to 2020
$3.6M
NIMH NIH HHS R01 MH111425
6 · The paper itself

Abstract

The value and uncertainty associated with choice alternatives constitute critical features relevant for decisions. However, the manner in which reward and risk representations are temporally organized in the brain remains elusive. Here we leverage the spatiotemporal precision of intracranial electroencephalography, along with a simple card game designed to elicit the unfolding computation of a set of reward and risk variables, to uncover this temporal organization. Reward outcome representations across wide-spread regions follow a sequential order along the anteroposterior axis of the brain. In contrast, expected value can be decoded from multiple regions at the same time, and error signals in both reward and risk domains reflect a mixture of sequential and parallel encoding. We further highlight the role of the anterior insula in generalizing between reward prediction error and risk prediction error codes. Together our results emphasize the importance of neural dynamics for understanding value-based decisions under uncertainty.

Indexed as

BrainRewardHumans

Identifiers

PMID38461343
PMCPMC10924934
OpenAlexW4392622920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.