Observational studyLipids in health and disease2024
Dyslipidemia versus obesity as predictors of ischemic stroke prognosis: a multi-center study in China.
Observational study in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 14 citations in OpenAlex.
- Associations of Whole Blood Minerals and Trace Elements with Body Composition in Overweight and Obese Patients: A Retrospective Cross-Sectional Study.Biological trace element research · 2026Article
- The impact of triglyceride-glucose index on short-term prognosis in patients with acute myocarditis.BMC cardiovascular disorders · 2026Article
- Assessment of Socio-Demographic and Clinical Characteristics of Stroke Patients of a Tertiary Hospital in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Clinical prediction model of invalid recanalization after complete reperfusion after thrombectomy in acute ischemic stroke patients: a large retrospective study.Journal of neurointerventional surgery · 2026Article
- Association between the triglyceride to high-density lipoprotein cholesterol ratio and 90-day post-stroke depression in acute ischemic stroke.Frontiers in psychiatry · 2026Article
- Circadian Syndrome Mediates the Association Between Body Roundness Index and Incident Stroke Risk in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.Behavioural neurology · 2026Article
- Associations of weight-derived markers with mortality in patients with Corona virus disease 2019: evidence from hospitals and patients.BMC pulmonary medicine · 2025Article
- Article
- Nonlinear association between hematocrit levels and short-term all-cause mortality in ICU patients with acute pancreatitis: insights from a retrospective cohort study.BMC gastroenterology · 2025Article
- Emergency Admission Plasma D-Dimer and Prothrombin Activity: Novel Predictors for Clinical Outcomes After Thrombectomy in Acute Ischemic Stroke With Large Artery Occlusion.CNS neuroscience & therapeutics · 2025Article
- Systemic inflammatory response index mediates the association between stroke and hypertension: a cross-sectional study from NHANES 2001 to 2016.Frontiers in neurology · 2025Article
- Nucleated red blood cell distribution in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2024Article
- An ensemble model for predicting dyslipidemia using 3-years continuous physical examination data.Frontiers in physiology · 2024Article
- Clinical multidimensional prediction model for futile reperfusion in acute ischemic stroke after endovascular thrombectomy.Frontiers in neurologyArticle
- Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke.Frontiers in neurologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis multicenter observational study aimed to determine whether dyslipidemia or obesity contributes more significantly to unfavorable clinical outcomes in patients experiencing a first-ever ischemic stroke (IS).
methodsThe study employed a machine learning predictive model to investigate associations among body mass index (BMI), body fat percentage (BFP), high-density lipoprotein (HDL), triglycerides (TG), and total cholesterol (TC) with adverse outcomes in IS patients. Extensive real-world clinical data was utilized, and risk factors significantly linked to adverse outcomes were identified through multivariate analysis, propensity score matching (PSM), and regression discontinuity design (RDD) techniques. Furthermore, these findings were validated via a nationwide multicenter prospective cohort study.
resultsIn the derived cohort, a total of 45,162 patients diagnosed with IS were assessed, with 522 experiencing adverse outcomes. A multifactorial analysis incorporating PSM and RDD methods identified TG (adjusted odds ratio (OR) = 1.110; 95% confidence interval (CI): 1.041-1.183; P < 0.01) and TC (adjusted OR = 1.139; 95%CI: 1.039-1.248; P < 0.01) as risk factors. However, BMI, BFP, and HDL showed no significant effect. In the validation cohort, 1410 controls and 941 patients were enrolled, confirming that lipid levels are more strongly correlated with the prognosis of IS patients compared to obesity (TC, OR = 1.369; 95%CI: 1.069-1.754; P < 0.05; TG, OR = 1.332; 95%CI: 1.097-1.618; P < 0.01).
conclusionThis study suggests that dyslipidemia has a more substantial impact on the prognosis of IS patients compared to obesity. This highlights the importance of prioritizing dyslipidemia management in the treatment and prevention of adverse outcomes in IS patients.
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