Evidence map›Paper›PMID 38461242›Full record

ArticleCell & bioscience2024

Single-cell transcriptome reveals a novel mechanism of C-Kit

Hui-Yi Li, Yu-Xuan Gao, Jun-Cheng Wu, Jing-Ze Li, Seng-Wang Fu, Ming-Yi Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. CD157Stem cell reports · 2026
    Article
  3. Review
  4. Review
  5. MertkImmunity, inflammation and disease · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hui-Yi Li *Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, No. 551, Pudong-South Road, Shanghai, 200120, China.
Yu-Xuan Gao *Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, No. 551, Pudong-South Road, Shanghai, 200120, China.
Jun-Cheng Wu *Departments of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, Jiangsu, China.
Jing-Ze LiEndoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Seng-Wang FuDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Rd, Shanghai, 200080, China. chenghong.fu@shgh.cn.
Ming-Yi XuDepartment of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, No. 551, Pudong-South Road, Shanghai, 200120, China. xumingyi@tongji.edu.cn.ORCID http://orcid.org/0000-0002-4834-3542
Shanghai East Hospital · CNShanghai Jiao Tong University · CNSoochow University · CN

Funding

Medical discipline Construction Project of Pudong Health Committee of Shanghai PWYgf2021-02National Natural Science Foundation of China 82200629National Natural Science Foundation of China 82270604Shanghai East hospital talent introduction project DFRC2022005
6 · The paper itself

Abstract

aimTo understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH).

methodsWe profiled single-LSEC from livers of control and MCD-fed mice. The functions of C-Kit

resultsThree special clusters of single-LSEC were differentiated. C-Kit

conclusionsHence, a novel transcriptomic view of LSECs was revealed to have heterogeneity and complexity in NASH. Importantly, a cluster of C-Kit

Indexed as

KIT proto-oncogene receptor tyrosine kinase (C-Kit)Liver sinusoidal endothelial cell (LSEC)MitophagyNon-alcoholic steatohepatitis (NASH)Single-cell RNA sequencing (scRNA-seq)

Identifiers

PMID38461242
PMCPMC10925010
OpenAlexW4392617899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.