Evidence map›Paper›PMID 38461231›Full record

ArticleJournal of nanobiotechnology2024

Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC.

Wenting Chen, Fangfang Hu, Qian Gao, Caiyun Zheng, Que Bai, Jinxi Liu, Na Sun, Wenhui Zhang, Yanni Zhang, Kai Dong and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Wenting ChenKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Fangfang HuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Qian GaoKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Caiyun ZhengKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Que BaiKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Jinxi LiuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Na SunKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Wenhui ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Yanni ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China.
Kai DongSchool of Pharmacy, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, People's Republic of China.
Tingli LuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 127 West Youyi Road, Xi'an, 710072, People's Republic of China. lutinglixinxin@nwpu.edu.cn.
Northwestern Polytechnical University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this therapy still needs to be improved by weakly acidic pH and over-expression of glutathione (GSH) in tumor microenvironment (TEM), which hinders its future application. Herein, we reported a multifunctional bimetallic composite nanoparticle MnO

Indexed as

NanoparticlesNeoplasmsTriple Negative Breast NeoplasmsAnimalsCell Line, TumorGallic AcidGlutathioneHumansHydrogen-Ion ConcentrationHydrogen PeroxideManganese CompoundsMiceOxidesReactive Oxygen SpeciesTumor MicroenvironmentGallic AcidGlutathioneHydrogen PeroxideManganese CompoundsOxidesReactive Oxygen SpeciesChemodynamic therapyFenton reactionGallic acidMetal-polyphenol networksReactive oxygen species

Identifiers

PMID38461231
PMCPMC10924346
OpenAlexW4392614932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.