Evidence map›Paper›PMID 38460975›Full record

Observational studyBMJ open respiratory research2024

Inhaled corticosteroids and

Christian Rønn, Peter Kamstrup, Christian Kjer Heerfordt, Pradeesh Sivapalan, Josefin Eklöf, Jonas Bredtoft Boel, Christian Ostergaard, Ram Benny Dessau, Mia Moberg, Julie Janner and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Inhaled Corticosteroid Use and Risk ofJournal of clinical medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Christian RønnSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark christian.roenn@regionh.dk.ORCID http://orcid.org/0000-0002-2193-4983
Peter KamstrupSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5499-7171
Christian Kjer HeerfordtSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8485-3235
Pradeesh SivapalanSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark.
Josefin EklöfSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark.
Jonas Bredtoft BoelDepartment of Clinical Microbiology, Copenhagen University Hospital-Herlev, Herlev, Denmark.
Christian OstergaardDepartment of Clinical Microbiology, Copenhagen University Hospital-Herlev, Herlev, Denmark.
Ram Benny DessauDepartment of Clinical Microbiology, Zealand University Hospital, Slagelse, Denmark.ORCID http://orcid.org/0000-0002-1497-6309
Mia MobergDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.
Julie JannerDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, Denmark.
Charlotte Suppli UlrikDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jens-Ulrik Stæhr JensenSection of Respiratory Medicine, Department of Internal Medicine, Copenhagen University Hospital-Gentofte, Copenhagen, Denmark.
Gentofte Hospital · DKUniversity of Copenhagen · DKHerlev Hospital · DKHvidovre Hospital · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInhaled corticosteroids (ICS) are widely used in patients with chronic obstructive pulmonary disease (COPD). However, ICS are associated with an increased risk of adverse effects.We aimed to determine whether an association between a lower respiratory tract culture with

designAn observational cohort study of outpatients with COPD in Denmark between 2010 and 2018.ICS exposure was categorised into four groups based on average daily consumption 1 year prior to inclusion: no use, low ICS dose (≤400 µg), moderate ICS dose (400-800 µg) and high ICS dose (>800 µg). Dose-response relationship was investigated by a multivariable Cox proportional hazards regression.

resultsOf the total 22 689 patients, 459 had lower respiratory tract cultures positive for

conclusionsWe found that ICS was associated with a high, dose-dependent increased hazard of

Indexed as

Pulmonary Disease, Chronic ObstructiveStenotrophomonas maltophiliaAdministration, InhalationAdrenal Cortex HormonesCohort StudiesHumansOutpatientsRetrospective StudiesAdrenal Cortex HormonesCOPD epidemiologyCOPD PathologyPulmonary Disease, Chronic Obstructive

Identifiers

PMID38460975
PMCPMC10928788
OpenAlexW4394741147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.