ArticleBiological psychiatry2024
Generalizable Links Between Borderline Personality Traits and Functional Connectivity.
Article in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Hemispheric asymmetries and network dysfunctions in adolescent depression: A neuroimaging study using resting-state functional magnetic resonance imaging.World journal of psychiatry · 2025Trial
- Feature overlap in transdiagnostic connectome-based models of sustained attention and autism symptoms.medRxiv : the preprint server for health sciences · 2026Article
- Spatial heterogeneity and subtypes of functional connectivity development in youth.Nature communications · 2026Article
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences.Nature neuroscience · 2025Article
- Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Investigating the correlation between cortical lateralization and personality traits in young Chinese adults through structural magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Decoding everyday levels of musical training from subcortical white-matter architecture.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundSymptoms of borderline personality disorder (BPD) often manifest during adolescence, but the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here, we aimed to investigate how multivariate patterns of functional connectivity are associated with borderline personality traits in large samples of young adults and adolescents.
methodsWe used functional magnetic resonance imaging data from young adults and adolescents from the HCP-YA (Human Connectome Project Young Adult) (n = 870, ages 22-37 years, 457 female) and the HCP-D (Human Connectome Project Development) (n = 223, ages 16-21 years, 121 female). A previously validated BPD proxy score was derived from the NEO Five-Factor Inventory. A ridge regression model with cross-validation and nested hyperparameter tuning was trained and tested in HCP-YA to predict BPD scores in unseen data from regional functional connectivity. The trained model was further tested on data from HCP-D without further tuning. Finally, we tested how the connectivity patterns associated with BPD aligned with age-related changes in connectivity.
resultsMultivariate functional connectivity patterns significantly predicted out-of-sample BPD scores in unseen data in young adults (HCP-YA p
conclusionsIndividual differences in functional connectivity in developmentally sensitive regions are associated with borderline personality traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.