Evidence map›Paper›PMID 38460322›Full record

ArticlePregnancy hypertension2024

Physiologic blood pressure patterns in pregnancies with mild chronic hypertension.

Rachel G Sinkey, Christina T Blanchard, Ayodeji Sanusi, Cooper Elkins, Jeff M Szychowski, Lorie M Harper, Alan T Tita

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pregnancy hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rachel G SinkeyCenter for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: rsinkey@uabmc.edu.
Christina T BlanchardCenter for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ayodeji SanusiCenter for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.
Cooper ElkinsDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA; University of Alabama Heersink School of Medicine, Birmingham, AL, USA.
Jeff M SzychowskiCenter for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Lorie M HarperDepartment of Obstetrics and Gynecology, University of Texas at Austin, Austin, TX, USA.
Alan T TitaCenter for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USThe University of Texas at Austin · US

Funding

The ACHIEVE Trial: Achieving longer gestation in preeclampsia via antihypertensive therapy.K23HL159331 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Rachel G Sinkey · 2022 to 2026
$884k
NHLBI NIH HHS K23 HL159331
6 · The paper itself

Abstract

objectivesTo assess physiologic blood pressure (BP) changes throughout pregnancy in patients with mild chronic hypertension (CHTN) who do and do not develop preeclampsia (PEC), compared to patients with normal BP. STUDY

designRetrospective cohort of singleton gestations with CHTN at a single tertiary center from 2000 to 2014 and a randomly selected cohort of patients without CHTN and normal pregnancy outcomes (NML) in the same time period with BP measurements available <12 weeks gestational age.

main outcome measuresThe primary outcome was gestational age (GA) at nadir of systolic and diastolic BP. Secondary outcomes included perinatal death, umbilical cord pH, maternal and neonatal length of stay, GA at delivery, and mode of delivery. Quadratic mixed models were used to estimate SBP and DBP throughout gestation.

resultsOf 367 pregnancies with CHTN, 268 (73%) had CHTN without PEC and 99 (27%) had CHTN with PEC; 198 NML pregnancies were used as a comparison group. The median GA nadir for patients in the NML, CHTN without PEC, and CHTN with PEC for SBP were 20, 24, and 21, respectively. For DBP, the median GA nadir were 22, 24, and 21 for patients in the NML, CHTN without PEC, and CHTN with PEC cohorts, respectively. Adverse secondary outcomes were more frequent in patients with CHTN who developed PEC.

conclusionsBP trajectories in pregnancy are different between patients with CHTN with PEC, CHTN without PEC, and patients with normal BP. These findings may be useful in assessing patients' risks for developing preeclampsia during pregnancy.

Indexed as

Blood PressureHypertensionPre-EclampsiaAdultCase-Control StudiesChronic DiseaseFemaleGestational AgeHumansPregnancyPregnancy Complications, CardiovascularPregnancy OutcomeRetrospective StudiesSeverity of Illness IndexBlood pressureChronic hypertensionPreeclampsiaPregnancy

Identifiers

PMID38460322
PMCPMC11162940
OpenAlexW4392611739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.