ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
High-Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem-Difluorinated Cyclopropanes.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Palladium-Catalyzed Fluoroallylation of Aldimine Esters With gem-Difluorocyclopropanes: Synthesis of Fluorinated α-Amino Acid Derivatives.Chemistry, an Asian journal · 2026Article
- Rhodium-catalyzed atroposelective C-H fluoroallylation of heteroarenes withChemical science · 2026Article
- High-Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem-Difluorinated Cyclopropanes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Transition-metal (TM) catalyzed reaction of gem-difluorinated cyclopropanes (gem-DFCPs) has drawn much attention recently. The reaction generally occurs via the activation of the distal C─C bond in gem-DFCPs by a low-valent TM through oxidative addition, eventually producing mono-fluoro olefins as the coupling products. However, achieving regioselective activation of the proximal C─C bond in gem-DFCPs that overcomes the intrinsic reactivity via TM catalysis remains elusive. Here, a new reaction mode of gem-DFCPs enabled by high-valent copper catalysis, which allows exclusive activation of the congested proximal C─C bond is presented. The reaction that achieves fluoroarylation of gem-DFCPs uses NFSI (N-fluorobenzenesulfonimide) as electrophilic fluoro reagent and arenes as the C─H nucleophiles, enabling the synthesis of diverse CF
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