Evidence map›Paper›PMID 38459695›Full record

ArticleBiophysical journal2024

Coupling of zinc and GTP binding drives G-domain folding in Acinetobacter baumannii ZigA.

Maximillian K Osterberg, Ally K Smith, Courtney Campbell, Daniel J Deredge, Timothy L Stemmler, David P Giedroc

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Microbiology spectrum · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Exploring metalloproteome remodeling in calprotectin-stressedbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. The interplay betweenInfection and immunity · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Maximillian K OsterbergDepartment of Chemistry, Indiana University, Bloomington, Indiana.
Ally K SmithDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.
Courtney CampbellDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan.
Daniel J DeredgeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland.
Timothy L StemmlerDepartment of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan.
David P GiedrocDepartment of Chemistry, Indiana University, Bloomington, Indiana. Electronic address: giedroc@indiana.edu.
Indiana University Bloomington · USUniversity of Maryland, Baltimore · USWayne State University · US

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial PathogensR35GM118157 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI DAVID P. GIEDROC · 2016 to 2026
$5.9M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
NIAID NIH HHS R01 AI101171NIGMS NIH HHS R35 GM118157NIGMS NIH HHS T32 GM066706NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

COG0523 proteins, also known as nucleotide-dependent metallochaperones, are a poorly understood class of small P-loop G3E GTPases. Multiple family members play critical roles in bacterial pathogen survival during an infection as part of the adaptive response to host-mediated "nutritional immunity." Our understanding of the structure, dynamics, and molecular-level function of COG0523 proteins, apart from the eukaryotic homolog, Zng1, remains in its infancy. Here, we use X-ray absorption spectroscopy to establish that Acinetobacter baumannii (Ab) ZigA coordinates Zn

Indexed as

Acinetobacter baumanniiZincBacteriaGuanosine DiphosphateGuanosine TriphosphateHumansNucleotidesProtein BindingGuanosine DiphosphateGuanosine TriphosphateNucleotidesZinc

Identifiers

PMID38459695
PMCPMC11052692
OpenAlexW4392590498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.