ArticleBiology direct2024
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway.
Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui, Jundong Wu
Open access · goldAbstract read
In one paragraphArticle in Biology direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors at 3 institutions in 1 country.
Lifang HeBreast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. hlf413@163.com.
Chuanghong SheThe Breast Center, People's Hospital of Jieyang, Jieyang, Guangdong, China. 2279370964@qq.com.
Sen JiangDepartment of Radiology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Zhaochang QiLaboratory for Breast Cancer Diagnosis and Treatment of Shantou University Medical College, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Zihao DengLaboratory for Breast Cancer Diagnosis and Treatment of Shantou University Medical College, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Likeng JiLaboratory for Breast Cancer Diagnosis and Treatment of Shantou University Medical College, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Yukun Cui *Laboratory for Breast Cancer Diagnosis and Treatment of Shantou University Medical College, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Jundong Wu *Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Cancer Hospital of Shantou University Medical College · CNShantou University · CNWenzhou Medical University · CN
Funding
2023 Science and Technology Innovation Strategy Project of Guangdong Province (Big Project + Task List), China STKJ2023009, 20230403Foundation of Basic and Applied Basic Research of Guangdong Province, China 2022A1515220202National Natural Science Foundation Cultivation Project of Cancer Hospital of Shantou University Medical College 2023GP005Science and Technology Special Fund of Guangdong Province of China 210728156901648， 210729156901814
6 · The paper itselfAbstract
backgroundMammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in breast cancer invasion, migration, and resistance against targeted therapy and chemotherapy. However, its role in the efficacy of endocrine therapy for the hormone receptor-positive (HR
methodsMENA expression levels in the clinical HR
resultsHR
conclusionsThis study demonstrated that downregulation of MENA promoted tamoxifen resistance in the HR
Indexed as
Breast NeoplasmsAnimalsAntineoplastic Agents, HormonalCell Line, TumorDrug Resistance, NeoplasmFemaleHumansMammalsMiceMice, NudeMicrofilament ProteinsProto-Oncogene Proteins c-aktSignal TransductionTamoxifenAntineoplastic Agents, HormonalEnah protein, humanMicrofilament ProteinsProto-Oncogene Proteins c-aktTamoxifenDrug resistanceHR + breast cancerMENAOrganoidTamoxifen
Identifiers
PMID38459605
PMCPMC10921784
OpenAlexW4392591473
What OpenQuestion holds
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LicenceCC BY
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