Evidence map›Paper›PMID 38459442›Full record

ArticleBMC genomics2024

scFSNN: a feature selection method based on neural network for single-cell RNA-seq data.

Minjiao Peng, Baoqin Lin, Jun Zhang, Yan Zhou, Bingqing Lin

Abstract read
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minjiao PengSchool of Mathematical Sciences, Shenzhen University, Nanshan, Shenzhen, 518060, Guangdong, China.
Baoqin LinExperimental Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, China.
Jun ZhangSchool of Mathematical Sciences, Shenzhen University, Nanshan, Shenzhen, 518060, Guangdong, China.
Yan ZhouSchool of Mathematical Sciences, Shenzhen University, Nanshan, Shenzhen, 518060, Guangdong, China.
Bingqing LinSchool of Mathematical Sciences, Shenzhen University, Nanshan, Shenzhen, 518060, Guangdong, China. bqlin@szu.edu.cn.

Funding

National Natural Science Foundation of China 11701386National Natural Science Foundation of China 12071305Natural Science Foundation of Guangdong Province of China 2023A1515011399
6 · The paper itself

Abstract

While single-cell RNA sequencing (scRNA-seq) allows researchers to analyze gene expression in individual cells, its unique characteristics like over-dispersion, zero-inflation, high gene-gene correlation, and large data volume with many features pose challenges for most existing feature selection methods. In this paper, we present a feature selection method based on neural network (scFSNN) to solve classification problem for the scRNA-seq data. scFSNN is an embedded method that can automatically select features (genes) during model training, control the false discovery rate of selected features and adaptively determine the number of features to be eliminated. Extensive simulation and real data studies demonstrate its excellent feature selection ability and predictive performance.

Indexed as

Neural Networks, ComputerSingle-Cell Gene Expression AnalysisCluster AnalysisComputer SimulationGene Expression ProfilingSequence Analysis, RNASingle-Cell AnalysisDeep neural networkFDR controlFeature selection

Identifiers

PMID38459442
PMCPMC10924397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.